Plexin A3 抗体 (Extracellular, N-Term)
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Quick Overview for Plexin A3 抗体 (Extracellular, N-Term) (ABIN7885234)
抗原
See all Plexin A3 (PLXNA3) 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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抗原表位
- AA 440-453, Extracellular, N-Term
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原理
- A Rabbit Polyclonal Antibody to Plexin-A3
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预测反应
- Rat - identical, human - 12,14 amino acid residues identical
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)KVRVDGSQDAQLYE, corresponding to amino acid residues 440-453 of mouse PLXNA3
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亚型
- IgG
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anti-Plexin A3 (PLXNA3) (AA 440-453), (Extracellular), (N-Term) antibody
PLXNA3 适用: 小鼠 IHC, WB, FACS, IF, LCI 宿主: 兔 Polyclonal unconjugated
anti-Plexin A3 (PLXNA3) (AA 1050-1100) antibodyPLXNA3 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200
FC: 2.5 μg per reaction
ICC: The optimal concentration should be determined by the user
IHC: 1:200
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7236268)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW)
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存液
- Without preservative
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- Plexin A3 (PLXNA3)
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别名
- PLXNA3
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背景
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Synonyms: PLXNA3, PLXN3, Semaphorin receptor SEX
Description: Plexins are type 1 transmembrane (TM) receptors acting as key regulatory proteins in a wide variety of developmental, regenerative and pathological processes. They are involved in guidance and motility of vascular, lymphatic vessel, and neuron growth, and in cancer metastasis.Plexin family includes 9 proteins: Plexin-A1-4, -B1-3, -C1 and -D1. Class A Plexins interact with the secreted class 3 Semaphorins, and require Neuropilins (nrps) as co-receptors.Plexin protein signaling results in cytosolic GTPase-activating protein activity including direct interactions with Rho GTPases and transient/catalytic interactions with Ras GTPases1,2.Plexin structure consists of an extracellular semaphorin domain, three Plexin-Semaphorin-Integrin (PSI) domains, and three immunoglobulin, Plexin, and transcription factor (IPT) domains. In addition, a single-spanning transmembrane domain, and a cytosolic region (CYTO) homologous with Ras GTPase-activating proteins (GAPs)2. The transmembrane region of Plexin-A3 is characterized by poly-glycine usually used for close helix-helix packing and aromatic residues that distort helix conformation and association. Plexin-A family members only have 22 residues spanning the membrane1.Mutations in Plexins have been reported in melanoma, lung, breast, pancreatic, and prostate cancers, strongly suggesting that their signaling may play a role in cancer development. Plexins are widely expressed in the nervous system and in the developing cerebral cortex2.
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基因ID
- 18846
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UniProt
- P70208
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途径
- Regulation of Cell Size
抗原
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