OPN3 抗体 (Extracellular, Loop 2)
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Quick Overview for OPN3 抗体 (Extracellular, Loop 2) (ABIN7885211)
抗原
See all OPN3 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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抗原表位
- AA 180-194, Extracellular, Loop 2
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原理
- A Rabbit Polyclonal antibody to Opsin 3 (extracellular)
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预测反应
- Mouse - 14 out of 15 amino acid identical Rat,human - 12 out of 15 amino acid identical
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)DIHGLG(S)TVDWRSKD, corresponding to amino acid residues 180 - 194 of mouse Opsin 3
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亚型
- IgG
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anti-Opsin 3 (OPN3) (AA 180-194), (Extracellular), (Loop 2) antibody
OPN3 适用: 小鼠 WB, IHC, FACS, LCI 宿主: 兔 Polyclonal unconjugated
anti-Opsin 3 (OPN3) (Internal Region) antibodyOPN3 适用: 人, 大鼠, 猴 IHC, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Opsin 3 (OPN3) (Internal Region) antibodyOPN3 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Opsin 3 (OPN3) (AA 313-402) antibodyOPN3 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Opsin 3 (OPN3) (C-Term) antibodyOPN3 适用: 人, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Opsin 3 (OPN3) (C-Term) antibodyOPN3 适用: 人, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Opsin 3 (OPN3) (C-Term) antibodyOPN3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Opsin 3 (OPN3) (C-Term) antibodyOPN3 适用: 人, 豚鼠, 马 WB 宿主: 兔 Polyclonal unconjugated
anti-Opsin 3 (OPN3) (AA 161-210) antibodyOPN3 适用: 人, 小鼠 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200
FC: 2.5 μg per reaction
ICC: The optimal concentration should be determined by the user
IHC: 1:300
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: BLP-OR023
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW)
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存液
- Without preservative
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- OPN3 (Opsin 3 (OPN3))
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别名
- OPN3
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背景
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Synonyms: OPN3, Encephalopsin, Panopsin
Description: Opsin 3 (OPN3), also known as encephalopsin or panopsin, is a member of the opsin family, which are light-sensitive G protein-coupled receptors (GPCRs) primarily known for their role in vision.1-3Opsins are found throughout the animal kingdom and while most vertebrates have a similar repertoire of 6-20 genes, mammals most commonly have eight opsins, although humans have nine.1-3Unlike Rhodopsin (or Opsin 2), the founding member of the opsin family, which is located in the retina and is essential for vision in low-light conditions, Opsin 3 has a more widespread expression pattern and functions that extend beyond traditional visual processing.1-3Opsin 3 is expressed in various tissues, including the brain, skin, testes, and lungs, among others.1-3Opsin 3 is abundantly expressed in the skin (a major light sensing organ). The function of Opsin 3 in photodetection and photosensitivity is not clear, but it appears to be based in a light-independent manner and through the interaction with MC1R, another GPCR that is crucial for the regulation of pigmentation in the skin and hair. 4An intriguing role for Opsin 3 was described in relation to regulation of energy metabolism. Opsin 3 was shown to regulate thermogenesis and lipolysis via a blue-light dependent mechanism in adipose tissue. 5As mentioned above, Opsin 3 is extensively expressed in several brain regions, including cortex, hippocampus and hypothalamus. Opsin 3 expression in brain regions associated with circadian rhythms, such as the hypothalamus, may suggest a possible role in regulating these rhythms. This connection could influence sleep-wake cycles and other circadian-related functions. In addition, Opsin 3 expression in regions like the hippocampus, a key area for memory and learning, indicates it might play a role in neural development or synaptic plasticity. This could have implications for learning, memory, and other cognitive functions. 4,6Finally, Opsin 3 has been detected in several cells of the immune system including T-cells and macrophages, implying that immune responses could be potentially regulated through light-related mechanisms.2,7
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基因ID
- 13603
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UniProt
- Q9WUK7
抗原
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