OPRL1 抗体 (C-Term, Intracellular)
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Quick Overview for OPRL1 抗体 (C-Term, Intracellular) (ABIN7885207)
抗原
See all OPRL1 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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抗原表位
- AA 337-352, C-Term, Intracellular
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原理
- A Rabbit Polyclonal Antibody to Nociceptin Receptor
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预测反应
- Mouse - identical, human - 13,16 amino acid residues identical
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)HREMQVSDRVRSIAKD, corresponding to amino acid residues 337-352 of rat OPRL1
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亚型
- IgG
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anti-Opiate Receptor-Like 1 (OPRL1) (AA 1-47) antibody
OPRL1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), ICC, IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Opiate Receptor-Like 1 (OPRL1) (AA 323-370) antibodyOPRL1 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Opiate Receptor-Like 1 (OPRL1) (Middle Region) antibodyOPRL1 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 山羊, 马, 兔, 绵羊, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
anti-Opiate Receptor-Like 1 (OPRL1) (AA 110-212) antibodyOPRL1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Opiate Receptor-Like 1 (OPRL1) (AA 1-370) antibodyOPRL1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Opiate Receptor-Like 1 (OPRL1) (AA 110-212) antibodyOPRL1 适用: 人 ELISA 宿主: 小鼠 Monoclonal 2A11 unconjugated
anti-Opiate Receptor-Like 1 (OPRL1) (C-Term) antibodyOPRL1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:600
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: The optimal concentration should be determined by the user
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7236167)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW)
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存液
- Without preservative
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- OPRL1 (Opiate Receptor-Like 1 (OPRL1))
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别名
- kappa-Type 3 opioid receptor
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背景
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Synonyms: κ-Type 3 opioid receptor, KOR-3, Orphanin FQ receptor, ROR-C, XOR1, ORL1, N/OFQ receptor
Description: Nociceptin/orphanin FQ (N/OFQ), a 17 amino acid peptide, is the endogenous agonist of the nociceptin/orphanin FQ peptide (NOP) receptor (previously termed ORL1 receptor) which belongs to the class A (Rhodopsin-like) γ subfamily of G protein-coupled receptors (GPCRs). Like all members the receptor has a common seven-transmembrane helical structure and is coupled predominantly to heterotrimeric Gi/Go proteins. N/OFQ receptor shows a high degree of structural homology with the μ-, δ- and κ-opioid receptors1. The intracellular events triggered by the binding of N/OFQ with the NOP receptor include inhibition of adenylyl cyclase, activation of phospholipase C (PLC) and of K+ channels, inhibition of Ca2+ channels, and activation of mitogen-activated protein-kinases (MAPKs). In neural tissues, the main effect is the inhibition of the release of neurotransmitters (acetylcholine, catecholamines, GABA, glutamate, 5-hydroxytryptamine, tachykinines)2.NOP receptor mRNA is detected in high levels in the cortex, anterior olfactory nucleus, lateral septum, hypothalamus, hippocampus, amygdala, central grey, pontine nuclei, interpeduncular nucleus, substantia nigra, raphe complex, locus coeruleus and spinal cord3.Studies with N/OFQ, NOP-selective agonists or antagonists, and receptor- or peptide-deficient mice have shown that the NOP system has important roles in the control of central and peripheral functions including pain, anxiety depression, hyperphagia and obesity, addiction, Parkinson's disease, cognition, food intake, learning and memory, locomotion, cough and micturition reflexes, cardiovascular homeostasis, intestinal motility and immune responses4.
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基因ID
- 29256
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UniProt
- P35370
抗原
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