NIPAL4 抗体 (2nd Extracellular Loop)
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Quick Overview for NIPAL4 抗体 (2nd Extracellular Loop) (ABIN7885202)
抗原
See all NIPAL4 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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抗原表位
- 2nd Extracellular Loop, AA 242-256
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原理
- A Rabbit Polyclonal Antibody to Magnesium Transporter NIPA4
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预测反应
- rat - 12,15 amino acid residues identical,Mouse - 13
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)EKVTTIMEMASKMKD, corresponding to amino acid residues 242-256 of human magnesium transporter NIPA4
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亚型
- IgG
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anti-NIPA-Like Domain Containing 4 (NIPAL4) (AA 9-37), (N-Term) antibody
NIPAL4 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB27750 unconjugated
anti-NIPA-Like Domain Containing 4 (NIPAL4) (AA 21-70) antibodyNIPAL4 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-NIPA-Like Domain Containing 4 (NIPAL4) (AA 16-45), (N-Term) antibodyNIPAL4 适用: 人, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-NIPA-Like Domain Containing 4 (NIPAL4) (2nd Extracellular Loop), (AA 242-256) antibodyNIPAL4 适用: 人 WB, FACS 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:400
FC: 5 μg per reaction
ICC: The optimal concentration should be determined by the user
IHC: The optimal concentration should be determined by the user
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7236151)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW)
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存液
- Without preservative
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- NIPAL4 (NIPA-Like Domain Containing 4 (NIPAL4))
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别名
- Magnesium transporter NIPA4
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背景
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Synonyms: Magnesium transporter NIPA4, NIPA-like protein 4, NIPA-like domain containing 4, Ichthyin, ICHYN, ICHN, Non-imprinted in Prader-Willi/Angelman syndrome region protein 4
Description: The NIPA family is currently comprised of 4 members- NIPA1-4. These members have a molecular similarity of 40 % . NIPA proteins are integral membrane proteins which function as Mg2+ transporters.The NIPA4 gene in mice is located on chromosome 11B1.1 and the human corresponding gene, hIchthyin is located on chromosome 5q33.3. Both genes share an 85 % amino acid similarity. Interestingly, NIPA2-4 show greater common identity in their ancestral invertebrate polypeptides than they do to NIPA1 suggesting different physiological roles. NIPA4 mediates Mg2+ uptake with a Km of 0.36 mM but unlike NIPA2, which is selective for Mg2+, it has been found to transport other cations as well.Mutations in the hIchthyin gene provide the basis of one form of autosomal-recessive congenital ichthyosis (ARCI). ARCI is a heterogenous group of disorders with abnormal differentiation and desquamation of the epidermis, leading to widespread scaling and erythema of the skin. To this day six homozygous mutations have been found, including one nonsense and five missense mutations, in a large number of consanguineous families presenting with ichthyosis. The function of ichthyin in skin differentiation is not fully understood but it has been suggested that because lipid dysfunctions are involved with the other ARCI disorders ichthyin might perform as a membrane receptor for trioxilins of the hepoxilin pathway.Although some NIPA proteins have been implicated as candidates for prader-willi syndrome their involvement remains unclear. Currently there is no evidence that NIPA4 is directly involved in the many complexities of the syndrome1.
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基因ID
- 348938
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UniProt
- Q0D2K0
抗原
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