NPTN 抗体 (Extracellular, N-Term)
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Quick Overview for NPTN 抗体 (Extracellular, N-Term) (ABIN7885193)
抗原
See all NPTN 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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抗原表位
- AA 194-210, Extracellular, N-Term
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原理
- A Rabbit Polyclonal Antibody to Neuroplastin
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预测反应
- Mouse,human - identical
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)RKNASNMEYRINKPRAE, corresponding to amino acid residues 194-210 of rat NPTN
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亚型
- IgG
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anti-Neuroplastin (NPTN) antibody
NPTN 适用: 人, 大鼠, 犬, 猴 WB, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 3C4 unconjugated
anti-Neuroplastin (NPTN) (N-Term) antibodyNPTN 适用: 人, 兔, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Neuroplastin (NPTN) (Internal Region) antibodyNPTN 适用: 人, 大鼠, 小鼠, 犬, 兔, 猴, Cow, 豚鼠, 马, Pig, Bat, Hamster IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Neuroplastin (NPTN) (Middle Region) antibodyNPTN 适用: 人, 大鼠, 小鼠, 犬 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Neuroplastin (NPTN) (AA 201-250) antibodyNPTN 适用: 人, 大鼠, 小鼠, 犬, 兔, 猴, Cow, 豚鼠, 马, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Neuroplastin (NPTN) (AA 29-200) antibodyNPTN 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Neuroplastin (NPTN) antibodyNPTN 适用: 人 WB, FACS 宿主: 小鼠 Monoclonal 25GB6900 unconjugated
anti-Neuroplastin (NPTN) (AA 194-210), (Extracellular), (N-Term) antibodyNPTN 适用: 大鼠 WB, IHC, IF, FACS, LCI 宿主: 兔 Polyclonal unconjugated
anti-Neuroplastin (NPTN) (AA 51-150) antibodyNPTN 适用: 人 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Neuroplastin (NPTN) antibodyNPTN 适用: 人, 大鼠, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:400
FC: 2.5 μg per reaction
ICC: The optimal concentration should be determined by the user
IHC: 1:120
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7236121)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW)
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存液
- Without preservative
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- NPTN (Neuroplastin (NPTN))
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别名
- NPTN
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背景
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Synonyms: NPTN, Glycoprotein 55/65, GP55, GP65, Np55, Np65, Stromal cell-derived receptor 1, SDR1, SDFR1
Description: The neuroplastins Np55 and Np65 comprise a superfamily of neuronal and synapse enriched immunoglobulin molecules. They play an important role in a number of vital synaptic and neuronal activities including cell adhesion in the case of Np65. Np65 and Np55 are identical in structure except for the N-terminal Np65-specific Ig1 domain. They also play a key role in the localization of GABA(A) receptors in inhibitory synapses.Neuroplastins have two Ig domains that project into the extracellular space and are followed by a single 21 amino-acid membrane spanning sequence and a 34 amino-acid intracellular domain. The intracellular domain is mostly comprised of charged and neutral residues but also of a few hydrophobic residues. The N-terminus includes a 28 amino-acid signal peptide. In addition, neuroplastins contain a glutamate residue in their transmembrane domain which is important for molecular interactions within the membrane region.Although Np55 and Np65 are closely related in structure there are significant differences in terms of their expression. Np65 is tissue specific and is expressed mostly in forebrain neurons in the cortex, hippocampus and striatum. It has an anterior-posterior axis of expression. It is also expressed in lower amounts in the thalamus and hypothalamus. In contrast, Np55 is expressed throughout the brain in varying amounts.Currently, neuroplastins are not directly implicated in human diseases however several possible links have been discovered. A single nucleotide polymorphism (SNP) in the human neuroplastin locus is associated with reduced cortical thickness and impaired intellectual ability in adolescents. Furthermore, other SNPs in neuroplastin has been found to be either a risk or protecting factor for schizophrenia in animal models1.
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基因ID
- 56064
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UniProt
- P97546
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途径
- Regulation of long-term Neuronal Synaptic Plasticity
抗原
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