NrCAM 抗体 (Extracellular, N-Term)
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Quick Overview for NrCAM 抗体 (Extracellular, N-Term) (ABIN7885176)
抗原
See all NrCAM (NRCAM) 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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抗原表位
- AA 583-597, Extracellular, N-Term
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原理
- A Rabbit Polyclonal Antibody to NrCAM
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预测反应
- human - 13,16 amino acid residues identical,Mouse - 15
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)KDNGELPN DERFSVD, corresponding to amino acid residues 583-597 of rat NrCAM
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亚型
- IgG
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anti-Neuronal Cell Adhesion Molecule (NRCAM) (AA 1192-1255) antibody
NRCAM 适用: 人 ELISA, ICC 宿主: 小鼠 Monoclonal 7D8C5 unconjugated
anti-Neuronal Cell Adhesion Molecule (NRCAM) (AA 30-845), (Extracellular Domain) antibody (Atto 390)NRCAM 适用: 小鼠 WB, ICC, IF 宿主: 小鼠 Monoclonal S364-51 Atto 390
anti-Neuronal Cell Adhesion Molecule (NRCAM) (AA 30-845), (Extracellular Domain) antibody (Atto 488)NRCAM 适用: 小鼠 WB, ICC, IF 宿主: 小鼠 Monoclonal S364-51 Atto 488
anti-Neuronal Cell Adhesion Molecule (NRCAM) (AA 30-845), (Extracellular Domain) antibody (PE)NRCAM 适用: 小鼠 WB, ICC, IF 宿主: 小鼠 Monoclonal S364-51 PE
anti-Neuronal Cell Adhesion Molecule (NRCAM) (AA 30-845), (Extracellular Domain) antibody (PerCP)NRCAM 适用: 小鼠 WB, ICC, IF 宿主: 小鼠 Monoclonal S364-51 PerCP
anti-Neuronal Cell Adhesion Molecule (NRCAM) (AA 30-845), (Extracellular Domain) antibody (HRP)NRCAM 适用: 小鼠 WB, ICC, IF 宿主: 小鼠 Monoclonal S364-51 HRP
anti-Neuronal Cell Adhesion Molecule (NRCAM) (AA 30-845), (Extracellular Domain) antibody (APC)NRCAM 适用: 小鼠 WB, ICC, IF 宿主: 小鼠 Monoclonal S364-51 APC
anti-Neuronal Cell Adhesion Molecule (NRCAM) (AA 30-845), (Extracellular Domain) antibody (Biotin)NRCAM 适用: 小鼠 WB, ICC, IF 宿主: 小鼠 Monoclonal S364-51 Biotin
anti-Neuronal Cell Adhesion Molecule (NRCAM) (AA 30-845), (Extracellular Domain) antibody (Atto 594)NRCAM 适用: 小鼠 WB, ICC, IF 宿主: 小鼠 Monoclonal S364-51 Atto 594
anti-Neuronal Cell Adhesion Molecule (NRCAM) (AA 30-845), (Extracellular Domain) antibody (FITC)NRCAM 适用: 小鼠 WB, ICC, IF 宿主: 小鼠 Monoclonal S364-51 FITC
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应用备注
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WB: 1:200
FC: 2.5 μg per reaction
ICC: The optimal concentration should be determined by the user
IHC: 1:200
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7236074)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW)
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存液
- Without preservative
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- NrCAM (NRCAM) (Neuronal Cell Adhesion Molecule (NRCAM))
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别名
- Neuronal cell adhesion molecule
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背景
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Synonyms: Neuronal cell adhesion molecule, Nr-CAM, NgCAM-related cell adhesion molecule, Ankyrin-binding cell adhesion molecule, Neuronal surface protein Bravo, HBravo
Description: NrCAM (Neuron-glia related cell adhesion molecule) is a cell adhesion molecule that belongs to the immunoglobulin-class (Ig) of the L1 family. NrCAM promotes axon growth and repulsion through trans homophilic binding of extracellular domains and intracellular coupling of the conserved cytoplasmic domains to the actin cytoskeleton. This interaction occurs through ankyrin B and ezrin-radixin-moesin adaptors. In addition, NrCAM is responsible for controlling dendritic spine densities, axonal guidance and targeting, and neurite outgrowth by acting as a co-receptor molecule at the neuronal cell surface1,2.NrCAM is highly expressed in the cortex1,3. Its structure contains a PDZ binding motif with the potential to bind PSD scaffold proteins PSD-95 and SAP102. The Ig domains of the protein mediate homophilic and heterophilic binding to multiple ligands2,3.Genetic polymorphisms in the NrCAM gene are linked to autism spectrum disorders, intellectual disability and addictive behavior. NrCAM knockout mice demonstrate autism spectrum disorder related behaviors including impaired sociability, cognitive inflexibility, hypersensitivity to sensory stimuli and altered visual cortical responses.
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基因ID
- 497815
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UniProt
- P97686
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途径
- Regulation of Cell Size
抗原
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