Neuroligin 3 抗体 (Extracellular, N-Term)
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Quick Overview for Neuroligin 3 抗体 (Extracellular, N-Term) (ABIN7885171)
抗原
See all Neuroligin 3 (NLGN3) 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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抗原表位
- AA 656-671, Extracellular, N-Term
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原理
- A Rabbit Polyclonal Antibody to Neuroligin 3
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预测反应
- Mouse,human - identical
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)SHITRRPNGKTWSTKR, corresponding to amino acid residues 656-671 of rat NLGN3
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亚型
- IgG
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anti-Neuroligin 3 (NLGN3) (AA 730-848) antibody (APC)
NLGN3 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S110-29 APC
anti-Neuroligin 3 (NLGN3) (AA 730-848) antibody (Biotin)NLGN3 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S110-29 Biotin
anti-Neuroligin 3 (NLGN3) (AA 730-848) antibody (FITC)NLGN3 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S110-29 FITC
anti-Neuroligin 3 (NLGN3) (AA 730-848) antibody (Atto 488)NLGN3 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S110-29 Atto 488
anti-Neuroligin 3 (NLGN3) (AA 730-848) antibody (Atto 390)NLGN3 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S110-29 Atto 390
anti-Neuroligin 3 (NLGN3) (AA 730-848) antibody (Atto 594)NLGN3 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S110-29 Atto 594
anti-Neuroligin 3 (NLGN3) (AA 730-848) antibody (PerCP)NLGN3 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S110-29 PerCP
anti-Neuroligin 3 (NLGN3) (AA 730-848) antibody (HRP)NLGN3 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S110-29 HRP
anti-Neuroligin 3 (NLGN3) (AA 730-848) antibody (PE)NLGN3 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S110-29 PE
anti-Neuroligin 3 (NLGN3) (AA 730-848) antibodyNLGN3 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S110-29 unconjugated
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应用备注
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WB: 1:200
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: 1:200
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7236056)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW)
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存液
- Without preservative
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- Neuroligin 3 (NLGN3)
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别名
- NLGN3
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背景
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Synonyms: NLGN3, Gliotactin homolog, HNL3, NL3
Description: Neuroligins (Nlgns) are a family of postsynaptic transmembrane cell adhesion proteins that play a crucial role in excitation and inhibition balance through their regulation of GABAergic and glutamatergic signaling. 5 Neuroligin family members have been identified in humans: NL1, NL2, NL3, NL4X, and NL4Y. NL 1-3 have close homologs in mice. Neurogilins have been identified in rodents, chicken, Drosophila, and C. elegans. Neuroligin structure contains extracellular acetylcholinesterase like domain that lacks esterase activity, a single transmembrane domain, and a short cytoplasmic tail containing a type I PDZ-domain-binding motif that functions in intracellular protein-protein interactions and signaling processes. Neuroligins and neurexins are known to interact with each other1,2.Neuroligin 3 is encoded by the Nlgn3 gene and seems to be ubiquitously expressed in the brain. Despite this fact, Neuroligin 3 functions in synaptic transmission appears to be region specific, affecting the somatosensory cortex and the hippocampus differently2.In humans, a missense mutation in Nlgn3 (Nlgn3R451C) causing reduced synaptic expression of the protein is associated with non-syndromic autism spectrum disorders. In addition, Nlgn3 deletion shows impaired social interaction and vocal communication in rodent models.
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基因ID
- 171297
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UniProt
- Q62889
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途径
- Synaptic Membrane
抗原
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