Neurexin 3 抗体 (Extracellular, N-Term)
Our Local Distributor
北京 101111
Quick Overview for Neurexin 3 抗体 (Extracellular, N-Term) (ABIN7885167)
抗原
See all Neurexin 3 (NRXN3) 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
-
-
抗原表位
- AA 39-52, Extracellular, N-Term
-
原理
- A Rabbit Polyclonal Antibody to Neurexin 3α
-
预测反应
- Mouse,human - identical
-
纯化方法
- Affinity purified on immobilized antigen.
-
免疫原
- (C)RYLRWDASTRSDLS, corresponding to amino acid residues 39-52 of rat Nrxn3alpha
-
亚型
- IgG
-
-
anti-Neurexin 3 (NRXN3) (N-Term) antibody
NRXN3 适用: 人, 大鼠 WB, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Neurexin 3 (NRXN3) (AA 1584-1643) antibodyNRXN3 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Neurexin 3 (NRXN3) (Internal Region) antibodyNRXN3 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Neurexin 3 (NRXN3) (AA 201-432) antibodyNRXN3 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Neurexin 3 (NRXN3) (AA 373-432) antibodyNRXN3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Neurexin 3 (NRXN3) (AA 436-462), (C-Term) antibodyNRXN3 适用: 人 WB 宿主: 兔 Polyclonal RB39595 unconjugated
anti-Neurexin 3 (NRXN3) (AA 294-549) antibodyNRXN3 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
anti-Neurexin 3 (NRXN3) (AA 1298-1494) antibodyNRXN3 适用: 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Neurexin 3 (NRXN3) (AA 39-52), (Extracellular), (N-Term) antibodyNRXN3 适用: 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
WB: 1:200
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: 1:400
IP: The optimal concentration should be determined by the user
-
说明
-
Negative Control: (ABIN7236041)
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- 0.2 mL double distilled water (DDW)
-
浓度
- 1 mg/mL
-
缓冲液
- PBS pH 7.4
-
储存液
- Without preservative
-
储存条件
- -20 °C
-
储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
-
-
- Neurexin 3 (NRXN3)
-
别名
- Nrxn3
-
背景
-
Synonyms: Nrxn3, NRX3A, Neurexin III-alpha
Description: Neurexins (NRXNs) are a family of transmembrane, synaptic adhesion molecules. NRXNS were identified as receptors for α-latrotoxin, a presynaptic toxin that triggers massive neurotransmitter release1. Neurexins are largely presynaptic proteins that form a trans-synaptic cell-adhesion complex with postsynaptic neuroligins2. They are encoded by three genes (NRXN1, NRXN2 and NRXN3), each using an upstream promoter to produce the longer α-isoform (α-NRXNs) and a downstream promoter to generate a shorter β-isoform (β-NRXNs).The α-isoforms and β-isoforms of each neurexin are single-pass transmembrane proteins maintaining identical transmembrane and intracellular domains but having distinct extracellular domains. NRXNs in neurons localize to the presynaptic membrane and bind trans-synaptically to postsynaptic adhesion molecules and receptors3. Neurexins are expressed in all neurons, and are subject to extensive alternative splicing, generating >1,000 splice variants, some of which exhibit highly regulated developmental and spatial expression patterns4.The structure of α-Neurexins is composed of 6 LNS domains (laminin, neurexin, sex-hormone-binding protein domain) and 3 EGF-like domains. In the mammalian brain they are known to interact with neuroligins, dystroglycan and neurexophilins. Neurexin 3α splicing can give rise to secreted and transmembrane forms of the protein. The biological function of the secreted form remains unknown5.Changes in Neurexin 3α are associated with autism, drug addiction and obesity6.
-
基因ID
- 116508
-
UniProt
- Q07310
抗原
-
