Neurexin 1 抗体 (Extracellular, N-Term)
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Quick Overview for Neurexin 1 抗体 (Extracellular, N-Term) (ABIN7885166)
抗原
See all Neurexin 1 (NRXN1) 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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抗原表位
- AA 546-560, Extracellular, N-Term
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原理
- A Rabbit Polyclonal Antibody to Neurexin 1α
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预测反应
- Mouse,human - identical
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)KPRHQKDAKHPQMIK, corresponding to amino acid residues 546-560 of rat Nrxn1alpha
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亚型
- IgG
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anti-Neurexin 1 (NRXN1) (C-Term) antibody
Verified NRXN1 适用: 人 WB, ELISA, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Neurexin 1 (NRXN1) (AA 184-363) antibodyNRXN1 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Neurexin 1 (NRXN1) (AA 31-130) antibodyNRXN1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Neurexin 1 (NRXN1) (AA 31-130) antibodyNRXN1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4F7 unconjugated
anti-Neurexin 1 (NRXN1) (N-Term) antibodyNRXN1 适用: 人 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Neurexin 1 (NRXN1) (AA 141-294) antibodyNRXN1 适用: 人 WB, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
anti-Neurexin 1 (NRXN1) (AA 77-110), (N-Term) antibodyNRXN1 适用: 人, 大鼠, 小鼠 WB 宿主: 兔 Polyclonal RB52794 unconjugated
anti-Neurexin 1 (NRXN1) (AA 31-310) antibodyNRXN1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Neurexin 1 (NRXN1) (AA 31-310) antibodyNRXN1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Neurexin 1 (NRXN1) (AA 1328-1421) antibodyKO Validated NRXN1 适用: 大鼠, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:400
FC: The optimal concentration should be determined by the user
ICC: 1:50
IHC: The optimal concentration should be determined by the user
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7236037)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW)
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存液
- Without preservative
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- Neurexin 1 (NRXN1)
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别名
- Nrxn1
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背景
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Synonyms: Nrxn1, Neurexin I-alpha
Description: Neurexins (NRXNs) are a family of transmembrane, synaptic adhesion molecules. NRXNS were identified as receptors for α-latrotoxin, a presynaptic toxin that triggers massive neurotransmitter release1. Neurexins are largely presynaptic proteins that form a trans-synaptic cell-adhesion complex with postsynaptic neuroligins2. They are encoded by three genes (NRXN1, NRXN2 and NRXN3), each using an upstream promoter to produce the longer α-isoform (α-NRXNs) and a downstream promoter to generate a shorter β-isoform (β- NRXNs).The α- and β-isoforms of each neurexin are single-pass transmembrane proteins maintaining identical transmembrane and intracellular domains but having distinct extracellular domains. NRXNs in neurons localize to the presynaptic membrane and bind trans-synaptically to postsynaptic adhesion molecules and receptors3. Neurexins are expressed in all neurons, and are subject to extensive alternative splicing, generating >1,000 splice variants, some of which exhibit highly regulated developmental and spatial expression patterns4. The extracellular domain of neurexin 1α (NRXN1α) is composed of three neurexin repeats (I, II, and III), which each contains the modules LNS-EGF-LNS. NRXN1α binds endogenous ligands including neuroligins, LRRTM family members, neurexophilin, α-dystroglycan, and GABA(A) receptors.NRXN1α gene mutations have been identified in neuropsychiatric diseases including Schizophrenia and Autism Spectrum Disorder5.
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基因ID
- 60391
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UniProt
- Q63372
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途径
- Synaptic Membrane, Skeletal Muscle Fiber Development
抗原
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