MT1 抗体 (3rd Intracellular Loop)
Our Local Distributor
北京 101111
Quick Overview for MT1 抗体 (3rd Intracellular Loop) (ABIN7885142)
抗原
See all MT1 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
-
-
抗原表位
- 3rd Intracellular Loop, AA 223-236
-
原理
- A Rabbit Polyclonal Antibody to Melatonin Receptor Type 1A
-
预测反应
- Rat,human - 13,14 amino acid residues identical
-
纯化方法
- Affinity purified on immobilized antigen.
-
免疫原
- (C)RVKPDNKPKLKPQD, corresponding to amino acid residues 223-236 of mouse MTNR1A
-
亚型
- IgG
-
-
anti-Metallothionein 1 (MT1) (AA 1-61) antibody
MT1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Metallothionein 1 (MT1) (AA 1-61) antibodyMT1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Metallothionein 1 (MT1) (AA 1-61) antibodyMT1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Metallothionein 1 (MT1) (AA 1-61) antibodyMT1 适用: 大鼠 WB, IHC, IP, IF/ICC 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
WB: 1:200
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: The optimal concentration should be determined by the user
IP: The optimal concentration should be determined by the user
-
说明
-
Negative Control: BLP-MR031
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- 0.2 mL double distilled water (DDW)
-
浓度
- 1 mg/mL
-
缓冲液
- PBS pH 7.4
-
储存液
- Without preservative
-
储存条件
- -20 °C
-
储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
-
-
- MT1 (Metallothionein 1 (MT1))
-
别名
- MT1
-
背景
-
Synonyms: MT1, Mel1a receptor, Mel-1A-R
Description: Melatonin (N-acetyl-5-methoxytryptamine) is a product of tryptophan metabolism. It is synthesized in the pineal gland and is secreted to control the circadian rhythm1-3. Melatonin is also synthesized in the gastrointestinal tract, retina, skin and other tissues where it acts in a autocrine or paracrine manner. The role of melatonin in these tissues is independent of its role in the circadian rhythm, where it plays a role in energy metabolism, physiological growth, differentiation and responsiveness in stress stimuli1. The pleiotropic effects of melatonin have given rise to various therapeutic possibilities for this molecule. For example, anti-stress, sexual dysfunction, obesity, gallbladder stones1,4. To date, the only therapeutic uses for melatonin remain to treat sleep disorders, depression, migraine and headaches1.Melatonin exerts its effects through two G-protein coupled receptors (GPCRs), melatonin receptor type 1 and melatonin receptor type 2 (MT1 and MT2). Like all GPCRs, they have seven transmembrane domains and extracellular N-terminal and cytoplasmic C-terminal tails. The binding of melatonin to either receptor activates Gi, thereby activating PLC, thus increasing intracellular Ca2+ levels. Both receptors structurally bind melatonin in the same manner, although MT2 displays a much higher affinity for the hormone. Just like melatonin levels are detected in many tissues, the expression patterns of the two receptors are also quite broad. For example, MT1 is detected in the brain, retina and kidneys and MT2 is expressed in brain and in the retina1.MT1 is involved in sleep regulation and might also have effects on peripheral vasoconstriction. MT2 may play an important physiological role in the retina and might regulate body temperature1.
-
基因ID
- 17773
-
UniProt
- Q61184
-
途径
- Transition Metal Ion Homeostasis
抗原
-
