LGI1 抗体 (LRRCT Domain)
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Quick Overview for LGI1 抗体 (LRRCT Domain) (ABIN7885117)
抗原
See all LGI1 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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抗原表位
- AA 206-218, LRRCT Domain
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原理
- A Rabbit Polyclonal Antibody to LGI1
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预测反应
- Mouse - identical, human - 12,13 amino acid residues identical
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)YKKRKINSLSPKD, corresponding to amino acid residues 206-218 of rat LGI1
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亚型
- IgG
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anti-Leucine-Rich, Glioma Inactivated 1 (LGI1) antibody
KD Validated LGI1 适用: 人 WB, IF (p), FACS 宿主: 兔 Monoclonal 24GB5950 unconjugated Recombinant Antibody
anti-Leucine-Rich, Glioma Inactivated 1 (LGI1) (AA 451-557) antibodyLGI1 适用: 小鼠, 大鼠 WB, ELISA, IF (p), IF (cc), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Leucine-Rich, Glioma Inactivated 1 (LGI1) (AA 37-113) antibody (Biotin)LGI1 适用: 小鼠 WB, IHC, IF, ICC 宿主: 小鼠 Monoclonal S283-7 Biotin
anti-Leucine-Rich, Glioma Inactivated 1 (LGI1) (AA 37-113) antibody (FITC)LGI1 适用: 小鼠 WB, IHC, IF, ICC 宿主: 小鼠 Monoclonal S283-7 FITC
anti-Leucine-Rich, Glioma Inactivated 1 (LGI1) (AA 37-113) antibody (PerCP)LGI1 适用: 小鼠 WB, IHC, IF, ICC 宿主: 小鼠 Monoclonal S283-7 PerCP
anti-Leucine-Rich, Glioma Inactivated 1 (LGI1) (AA 37-113) antibody (PE)LGI1 适用: 小鼠 WB, IHC, IF, ICC 宿主: 小鼠 Monoclonal S283-7 PE
anti-Leucine-Rich, Glioma Inactivated 1 (LGI1) (AA 37-113) antibody (Atto 390)LGI1 适用: 小鼠 WB, IHC, IF, ICC 宿主: 小鼠 Monoclonal S283-7 Atto 390
anti-Leucine-Rich, Glioma Inactivated 1 (LGI1) (AA 37-113) antibody (Atto 488)LGI1 适用: 小鼠 WB, IHC, IF, ICC 宿主: 小鼠 Monoclonal S283-7 Atto 488
anti-Leucine-Rich, Glioma Inactivated 1 (LGI1) (AA 37-113) antibody (Atto 594)LGI1 适用: 小鼠 WB, IHC, IF, ICC 宿主: 小鼠 Monoclonal S283-7 Atto 594
anti-Leucine-Rich, Glioma Inactivated 1 (LGI1) (AA 37-113) antibody (APC)LGI1 适用: 小鼠 WB, IHC, IF, ICC 宿主: 小鼠 Monoclonal S283-7 APC
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应用备注
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WB: 1:200
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: The optimal concentration should be determined by the user
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7235886)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW)
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存液
- Without preservative
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- LGI1 (Leucine-Rich, Glioma Inactivated 1 (LGI1))
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别名
- Leucine-rich glioma-inactivated protein 1
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背景
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Synonyms: Leucine-rich glioma-inactivated protein 1, Epitempin-1, EPT
Description: The leucine-rich glioma inactivated (LGI) gene subfamily contains four highly conserved members (LGI1, 2, 3 and 4), which have been described in human, mouse and other mammalians. LGI1 is mainly expressed in the dentate gyrus and the CA3 field of the hippocampus1.The predicted structure of the LGI1 protein comprises, starting from the N-terminal, a signal peptide, four leucine-rich repeats (LRR) flanked on both sides by conserved cysteine clusters, and seven copies of a repeat of about 45 residues, named EPTP or EAR, probably forming a β-propeller structural domain. Both LRR and β-propeller domains mediate protein-protein interactions, each motif defining a distinct family of proteins.LGI1 is associated with a post-synaptic complex containing PSD-95 and ADAM22, a receptor associated with the post-synaptic membrane. Through specific binding to ADAM22, LGI1 participates in the control of synaptic strength at excitatory synapses, whose malfunction may result in epilepsy.LGI1 has been linked to several different clinical phenotypes including: malignant progression of glioma and autosomal dominant lateral temporal epilepsy, a rare familial partial epilepsy syndrome. The LGI1 gene has been shown to be frequently downregulated in malignant gliomas and to regulate invasiveness of some glioma cell lines by driving the expression of matrix metalloproteinases through the ERK 1/2 pathway. These findings suggest that LGI1 may serve as a tumor metastasis suppressor gene2. In addition, antibodies to LGI1 complexed with the KV1.1 potassium channel have been found in brain extracts from patients with limbic encephalitis3.
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基因ID
- 252892
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UniProt
- Q8K4Y5
抗原
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