HOMER3 抗体 (Intracellular)
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Quick Overview for HOMER3 抗体 (Intracellular) (ABIN7885083)
抗原
See all HOMER3 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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抗原表位
- AA 155-169, Intracellular
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原理
- A Rabbit Polyclonal Antibody to Homer3
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预测反应
- Human - identical, mouse - 14,15 amino acid residues identical
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)RSQSADAPGPTERER, corresponding to amino acid residues 155 - 169 of rat Homer3
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亚型
- IgG
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anti-Homer Homolog 3 (Drosophila) (HOMER3) antibody
HOMER3 适用: 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Homer Homolog 3 (Drosophila) (HOMER3) (AA 281-308) antibodyHOMER3 适用: 人, 小鼠 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB21915 unconjugated
anti-Homer Homolog 3 (Drosophila) (HOMER3) (Center) antibodyHOMER3 适用: 人 WB, IHC (p), IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Homer Homolog 3 (Drosophila) (HOMER3) (AA 282-360) antibodyHOMER3 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Homer Homolog 3 (Drosophila) (HOMER3) (AA 1-177) antibodyHOMER3 适用: 大鼠 WB, IHC, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Homer Homolog 3 (Drosophila) (HOMER3) (AA 1-361) antibodyHOMER3 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Homer Homolog 3 (Drosophila) (HOMER3) (pThr36) antibodyHOMER3 适用: 人, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Homer Homolog 3 (Drosophila) (HOMER3) (AA 151-361) antibodyHOMER3 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Homer Homolog 3 (Drosophila) (HOMER3) (AA 155-169), (Intracellular) antibodyHOMER3 适用: 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Homer Homolog 3 (Drosophila) (HOMER3) (AA 82-131) antibodyHOMER3 适用: 人, 大鼠, 犬, 马, Cow, Pig, Bat, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: 1:1000
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7235770)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW)
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存液
- Without preservative
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- HOMER3 (Homer Homolog 3 (Drosophila) (HOMER3))
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别名
- Homer protein homolog 3
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背景
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Synonyms: Homer protein homolog 3, Homer scaffold protein 3, VESL3, Homer-3
Description: The HOMER protein family includes Homer1, 2, and 3. These proteins are mainly expressed in the neuronal post-synaptic density (PSD) where they play a role in post-synaptic signaling and receptor trafficking by forming multivalent links with various receptors and PSD scaffolding proteins. The expression level of Homer proteins in non-neural tissues is very low in comparison with that in the nervous system, HOMER3 also expressed in the lung, spleen, kidney and ovary. In the mouse brain HOMER3 is concentrated in the dendritic spines of Purkinje cells connecting the parallel fibers and is also present in their axons, In the hippocampus, HOMER3 is concentrated in the CA2-CA3 regions1,2.All three proteins in the HOMER family have several isoforms as a result of alternative splicing, HOMER3 are shown to exist in both long and short forms, the latter without the C-terminal coiled-coil domains. HOMER3 mRNA is subject to alternative splicing at five different sites giving rise to ten variants of HOMER3 proteins. HOMER1b and HOMER3 have been shown to form a tetramer via the carboxy-terminal domain3.HOMER3 directly binds to type I metabotropic glutamate receptors, which act via phospholipase C to stimulate IP3-mediated release of Ca2+ from intracellular vesicles3.HOMER proteins have also been implicated in axon guidance during brain development4.HOMER3 can regulate transcription and play a very important role in the differentiation and development for some tissues such as muscle and the nervous system. Studies show that HOMER3 abnormal expression plays a role in acute myeloid leukemia (AML). Heterologous expression of HOMER3 in K562 cells inhibits proliferation, influences the cell cycle profile, affects apoptosis and also promotes cell differentiation5.
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基因ID
- 29548
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UniProt
- Q9Z2X5
抗原
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