GRM2 抗体 (Extracellular, N-Term)
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Quick Overview for GRM2 抗体 (Extracellular, N-Term) (ABIN7885060)
抗原
See all GRM2 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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抗原表位
- Extracellular, N-Term
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原理
- A Rabbit Polyclonal Antibody to Metabotropic Glutamate Receptor 2
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预测反应
- Mouse,human,dog,monkey - identical
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- SLSRGADGSRHIC, corresponding to amino acids 109-121 of rat mGluR2
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亚型
- IgG
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anti-Glutamate Receptor, Metabotropic 2 (GRM2) (AA 414-558) antibody
GRM2 适用: 人 WB, ELISA, FACS 宿主: 小鼠 Monoclonal 6E4F6 unconjugated
anti-Glutamate Receptor, Metabotropic 2 (GRM2) (AA 414-558) antibodyGRM2 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 4A10B9 unconjugated
anti-Glutamate Receptor, Metabotropic 2 (GRM2) (N-Term) antibodyGRM2 适用: 人, 兔, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Metabotropic 2 (GRM2) (N-Term) antibodyGRM2 适用: 人, 大鼠, 小鼠, Cow, 犬, 兔, Hamster, Bat, Pig WB, IHC, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Metabotropic 2 (GRM2) antibodyGRM2 适用: 人 WB, IF 宿主: 兔 Monoclonal unconjugated
anti-Glutamate Receptor, Metabotropic 2 (GRM2) (Extracellular), (N-Term) antibodyGRM2 适用: 大鼠 WB, IHC, IF, IC, LCI 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Metabotropic 2 (GRM2) (Internal Region) antibodyVerified GRM2 适用: 人 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Glutamate Receptor, Metabotropic 2 (GRM2) (AA 93-221) antibodyGRM2 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Metabotropic 2 (GRM2) (N-Term) antibodyGRM2 适用: 人, 大鼠, 犬, 兔, Hamster, Bat IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Metabotropic 2 (GRM2) (AA 801-872) antibodyGRM2 适用: 大鼠 WB, ELISA, IF (p), IHC (p), ICC, IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200-1:400
FC: The optimal concentration should be determined by the user
ICC: 1:100
IHC: The optimal concentration should be determined by the user
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7235685)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW)
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存液
- Without preservative
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- GRM2 (Glutamate Receptor, Metabotropic 2 (GRM2))
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别名
- Metabotropic glutamate receptor 2
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背景
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Synonyms: Metabotropic glutamate receptor 2, GRM2, mGlu2, GPRC1B
Description: L-Glutamate, the major excitatory neurotransmitter in the central nervous system, operates through several receptors that are categorized as ionotropic (ligand-gated cation channels) or metabotropic (G-protein coupled receptors). The metabotropic glutamate receptor family includes eight members (mGluR1-8) that have been divided into three groups based on their sequence homology, pharmacology and signal transduction.Group II of the metabotropic glutamate receptors includes the mGluR2 and mGluR3 receptors. The receptors present the typical G-protein coupled receptor (GPCR) signature topology: seven transmembrane domains with a large extracellular N-terminus domain that contains the glutamate binding site, and an intracellular C-terminus.1,2 mGluR2 and mGluR3 are coupled to Gi/Go and hence inhibit cAMP formation following receptor activation.1,2mGluR2 is widely distributed throughout the brain with high expression in several limbic areas including the cortex, hippocampus and amygdala. mGluR2 is localized primarily presynaptically, although postsynaptic localization has also been described.In line with its presynaptic localization, mGluR2 is thought to function as an autoreceptor in a negative feedback mechanism that suppress further release of glutamate from the cell on which it is expressed.The involvement of mGluR2 in neuronal excitability and synaptic transmission suggests that modulation of this receptor is a promising strategy for the treatment of neurological and neuropsychiatric disorders such as anxiety, schizophrenia, and pain.3
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基因ID
- 24415
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UniProt
- P31421
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途径
- cAMP Metabolic Process, Dicarboxylic Acid Transport
抗原
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