GRPR 抗体 (3rd Extracellular Loop)
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Quick Overview for GRPR 抗体 (3rd Extracellular Loop) (ABIN7885033)
抗原
See all GRPR 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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抗原表位
- 3rd Extracellular Loop, AA 287-300
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原理
- A Rabbit Polyclonal Antibody to Bombesin Receptor 2/Gastrin-releasing Peptide Receptor
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预测反应
- Rat,mouse,dog - identical
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)RSYHYSEVDTSMLH, corresponding to amino acid residues 287-300 of human BB2R
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亚型
- IgG
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anti-Gastrin-Releasing Peptide Receptor (GRPR) antibody
GRPR 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Gastrin-Releasing Peptide Receptor (GRPR) (AA 326-384) antibodyGRPR 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Gastrin-Releasing Peptide Receptor (GRPR) (AA 235-384) antibodyGRPR 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Gastrin-Releasing Peptide Receptor (GRPR) (3rd Extracellular Loop), (AA 287-300) antibodyGRPR 适用: 人 WB, IHC, IF, IC, LCI 宿主: 兔 Polyclonal unconjugated
anti-Gastrin-Releasing Peptide Receptor (GRPR) antibodyGRPR 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Gastrin-Releasing Peptide Receptor (GRPR) (Extracellular Domain) antibodyGRPR 适用: 人, Bat, 犬, 猴, Pig, 马, 兔 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Gastrin-Releasing Peptide Receptor (GRPR) (AA 130-160), (Middle Region) antibodyGRPR 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Gastrin-Releasing Peptide Receptor (GRPR) (Internal Region) antibodyGRPR 适用: 人, 小鼠, 大鼠 WB, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Gastrin-Releasing Peptide Receptor (GRPR) (Cytoplasmic Domain) antibodyGRPR 适用: 人, 小鼠, 大鼠, Bat, 犬, 猴, Pig, Cow, Hamster IHC, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Gastrin-Releasing Peptide Receptor (GRPR) (AA 123-152) antibodyGRPR 适用: 人 IHC (p) 宿主: 兔 Polyclonal RB24634 unconjugated
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应用备注
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WB: 1:200-1:500
FC: The optimal concentration should be determined by the user
ICC: 1:100
IHC: 1:50
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7235573)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW)
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存液
- Without preservative
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- GRPR (Gastrin-Releasing Peptide Receptor (GRPR))
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别名
- BB2R
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背景
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Synonyms: BB2R, Gastrin-releasing peptide receptor, GRP-preferring bombesin receptor
Description: Bombesin receptor 2 (BB2) is a member of a family of receptors that binds the 14 amino acid peptide, bombesin. Bombesin was first isolated from frog skin and it was later established that mammals express endogenous bombesin-like peptides such as gastrin-releasing peptide (GRP, a 27 amino acid homologue) and neuromedin B (NMB, a 10 amino acid homologue).BB2 is the preferred receptor for GRP and hence it is also referred to as GRP receptor or GRP-R.1 BB1 is the preferred receptor for NMB and therefore it is also known as NMB-R. A third member (called BB3) of the bombesin receptor family has been recognized but the endogenous mammalian ligand for this receptor remains to be identified.All three bombesin receptors are members of the seven-transmembrane domain, G protein-coupled receptor (GPCR) superfamily. BB2 is coupled to a Gq/11 protein that activates phospholipase C (PLC) and leads to production of inositol 1,4,5-trisphosphate (InsP3), intracellular Ca2+ mobilization, and cell growth.2GRP (through its binding to BB2) plays an essential role in the release of hormones in the intestinal tract, the regulation of smooth muscle contraction, and the secretion of pancreatic enzymes.2 In the brain, BB2 has been implicated in regulating feeding behavior, thermoregulation, and memory formation.3Finally, BB2 is overexpressed in several human tumors including breast, prostate, and lung, where it acts as a growth factor receptor inducing tumor growth. BB2 is considered a potential target for the development of both diagnostics and anti-cancer therapies.4
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基因ID
- 2925
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UniProt
- P30550
抗原
-
