SH3G2 抗体 (Intracellular)
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Quick Overview for SH3G2 抗体 (Intracellular) (ABIN7884928)
抗原
See all SH3G2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 255-269, Intracellular
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原理
- A rabbit polyclonal antibody to Endophilin-A1
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预测反应
- Rat - identical. Human - 14 out of 15 amino acids identical
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)YQPKPRMSLEFATGD, corresponding to amino acid residues 255 - 269 of mouse SH3GL2
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亚型
- IgG
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anti-Endophilin-A1 (SH3G2) (AA 64-124) antibody
SH3G2 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 5A6 unconjugated
anti-Endophilin-A1 (SH3G2) (AA 256-276) antibodyKO Validated SH3G2 适用: 小鼠, 大鼠 WB, IHC, IHC (p), ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Endophilin-A1 (SH3G2) (AA 65-292) antibodySH3G2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Endophilin-A1 (SH3G2) (AA 1-270) antibodySH3G2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Endophilin-A1 (SH3G2) (AA 1-270) antibodySH3G2 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Endophilin-A1 (SH3G2) (AA 245-279), (C-Term) antibodySH3G2 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal RB52937 unconjugated
anti-Endophilin-A1 (SH3G2) (AA 127-158) antibodySH3G2 适用: 人 WB 宿主: 兔 Polyclonal RB52936 unconjugated
anti-Endophilin-A1 (SH3G2) antibodySH3G2 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Endophilin-A1 (SH3G2) (AA 64-124) antibodySH3G2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Endophilin-A1 (SH3G2) (AA 1-279) antibodySH3G2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2C4 unconjugated
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应用备注
- The optimal concentration should be determined by the user
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- SH3G2 (Endophilin-A1 (SH3G2))
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别名
- SH3GL2
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背景
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Synonyms: SH3 domain-containing GRB2-like protein 2, EEN-B1, SH3 domain protein 2A, SH3GL2
Description:
Endophilin-1 is a member of the Endophilin family, a group of proteins characterized by the presence of BAR (Bin/Amphiphysin/Rvs) and SH3 (Src Homology 3) domains.
The Endophilin family is primarily divided into two subfamilies. Endophilin A , that includes subunits A1, A2 and A3, is predominantly involved in membrane remodeling processes such clathrin-mediated and clathrin-independent endocytic pathways, especially in neurons. The Endophilin B subfamily includes subunits B1 and B2, and is more implicated in mitochondrial dynamics, autophagy and apoptosis.1,2
Endophilin-A1 is expressed almost exclusively in the brain, particularly in synaptic terminals in neurons, consistent with a neuronal specialization for membrane trafficking and synaptic function. It is essential for synaptic vesicle endocytosis, where it recruits and organizes proteins at sites of high membrane curvature to facilitate the formation and recycling of clathrin-coated vesicles at synaptic terminals. It is critical for dendritic spine morphogenesis, synaptic stabilization, and plasticity, supporting both excitatory and inhibitory synaptic organization.3,4
Changes in Endophilin-1 expression are linked to several neurodegenerative disease, most notably, Alzheimer's (AD) and Parkinson disease. Increased expression of Endophilin-1 has been observed in the brains of patients with AD and in transgenic mouse models of the disease.5,6
Endophilin-1 was identified as a Parkinson's disease risk locus and in addition, it was found to be upregulated in a mouse model of the disease.7,8
In summary, Endophilin-A1 not only serves as a compelling target for understanding synaptic biology but also holds promise as a biomarker and therapeutic candidate in neurodegenerative and neuropsychiatric diseases.
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基因ID
- 20404
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UniProt
- Q62420
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途径
- Neurotrophin Signaling Pathway, EGFR Downregulation
抗原
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