DRD3 抗体 (Extracellular, N-Term)
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Quick Overview for DRD3 抗体 (Extracellular, N-Term) (ABIN7884919)
抗原
See all DRD3 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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抗原表位
- AA 15-29, Extracellular, N-Term
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原理
- A Rabbit Polyclonal Antibody to D3 Dopamine Receptor
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预测反应
- Mouse - identical, human - 12,15 amino acid residues identical
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- CGAENSTGVNRARPH, corresponding to amino acid residues 15-29 of rat DRD3
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亚型
- IgG
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anti-Dopamine Receptor D3 (DRD3) (AA 352-446) antibody
DRD3 适用: 人, 大鼠, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Dopamine Receptor D3 (DRD3) (AA 15-29), (Extracellular), (N-Term) antibodyKO Validated DRD3 适用: 大鼠 WB, IHC, IF, FACS, LCI 宿主: 兔 Polyclonal unconjugated
anti-Dopamine Receptor D3 (DRD3) (AA 213-329) antibodyDRD3 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Dopamine Receptor D3 (DRD3) (Cytoplasmic Domain) antibodyDRD3 适用: 人, 小鼠, 犬, 马, Pig, 猴, Bat, Hamster IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Dopamine Receptor D3 (DRD3) antibodyDRD3 适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB5840 unconjugated Recombinant Antibody
anti-Dopamine Receptor D3 (DRD3) (AA 352-446) antibody (AbBy Fluor® 594)DRD3 适用: 人, 大鼠, 小鼠 WB, IF (cc), IF (p) 宿主: 兔 Polyclonal AbBy Fluor® 594
anti-Dopamine Receptor D3 (DRD3) (Internal Region) antibodyDRD3 适用: 人, 大鼠, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Dopamine Receptor D3 (DRD3) (AA 213-329) antibodyDRD3 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Dopamine Receptor D3 (DRD3) antibodyDRD3 适用: 人 WB, ELISA 宿主: 兔 Monoclonal 5B10 unconjugated Recombinant Antibody
anti-Dopamine Receptor D3 (DRD3) antibodyDRD3 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
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应用备注
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WB: 1:200
FC: 5 μg per reaction
ICC: The optimal concentration should be determined by the user
IHC: 1:100
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7235243)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW)
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存液
- Without preservative
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- DRD3 (Dopamine Receptor D3 (DRD3))
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别名
- DRD3
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背景
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Synonyms: DRD3
Description: The D3 Dopamine Receptor (D3 receptor) is one of five receptors that mediate the effects of the catecholamine neurotransmitter dopamine. Dopamine regulates a variety of functions including locomotor activity, emotion, positive reinforcement, food intake, and endocrine regulation. The dopaminergic system has been extensively studied in the last thirty years mainly because its dysregulation has been linked to several neurological and neuropsychiatric diseases including Parkinson's disease and schizophrenia.1All five dopamine receptors belong to the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily.Historically, the five receptors have been divided into two subfamilies based on pharmacological and structural considerations: the D1-like subfamily (that includes the D1 and D5 subtypes) and the D2-like subfamily (that includes the D2-, D3- and D4 subtypes).1The D1-like receptors are coupled to Gs-type G proteins and enhance adenylate cyclase activity while the D2-like receptors are coupled to Gi-type G proteins and inhibit adenylate cyclase activity.1The D3 receptor distribution in the brain is relatively restricted to limbic areas such as striatum, islands of Calleja and olfactory tubercle. In the periphery, it is expressed in the kidney particularly in proximal tubules.1The exact physiological function of the D3 receptor remains to be fully elucidated. In studies using D3 receptor knockout mice, the most prominent dysfunction was the development of rennin-dependent hypertension. Potential roles in reinforcement and reward behaviors have also been suggested as well as roles in neuropsychiatric disorders such as drug abuse and schizophrenia.2
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基因ID
- 29238
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UniProt
- P19020
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途径
- Regulation of Systemic Arterial Blood Pressure by Hormones, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Proton Transport, Negative Regulation of Transporter Activity
抗原
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