DPYSL2 抗体 (Intracellular)
Our Local Distributor
北京 101111
Quick Overview for DPYSL2 抗体 (Intracellular) (ABIN7884910)
抗原
See all DPYSL2 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
-
-
抗原表位
- AA 504-517, Intracellular
-
原理
- A Rabbit Polyclonal Antibody to CRMP-2
-
预测反应
- Mouse,human - identical
-
纯化方法
- Affinity purified on immobilized antigen.
-
免疫原
- CEVSVTPKTVTPAS, corresponding to amino acid residues 504-517 of rat CRMP2
-
亚型
- IgG
-
-
anti-Dihydropyrimidinase-Like 2 (DPYSL2) (C-Term) antibody
DPYSL2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Dihydropyrimidinase-Like 2 (DPYSL2) (AA 470-571) antibodyDPYSL2 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1F11 unconjugated
anti-Dihydropyrimidinase-Like 2 (DPYSL2) (AA 1-572) antibodyDPYSL2 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Dihydropyrimidinase-Like 2 (DPYSL2) antibodyDPYSL2 适用: 人 WB, IF 宿主: 兔 Monoclonal unconjugated
anti-Dihydropyrimidinase-Like 2 (DPYSL2) (AA 400-500) antibodyKO Validated DPYSL2 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Dihydropyrimidinase-Like 2 (DPYSL2) (C-Term) antibodyDPYSL2 适用: 人, 小鼠, 大鼠 WB, IF, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Dihydropyrimidinase-Like 2 (DPYSL2) (AA 463-492) antibodyDPYSL2 适用: 人, 小鼠 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 33CT11-40-3 unconjugated
anti-Dihydropyrimidinase-Like 2 (DPYSL2) (AA 480-529) antibodyDPYSL2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Dihydropyrimidinase-Like 2 (DPYSL2) (Thr509) antibodyDPYSL2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Dihydropyrimidinase-Like 2 (DPYSL2) antibodyKD Validated DPYSL2 适用: 人 WB, FACS 宿主: 兔 Monoclonal 25GB2985 unconjugated Recombinant Antibody
-
-
应用备注
-
WB: 1:200
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: 1:300
IP: The optimal concentration should be determined by the user
-
说明
-
Negative Control: (ABIN7235204)
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- 0.2 mL double distilled water (DDW)
-
浓度
- 1 mg/mL
-
缓冲液
- PBS pH 7.4
-
储存液
- Without preservative
-
储存条件
- -20 °C
-
储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
-
-
- DPYSL2 (Dihydropyrimidinase-Like 2 (DPYSL2))
-
别名
- CRMP-2
-
背景
-
Synonyms: CRMP-2, Collapsin response mediator protein 2, Dihydropyrimidinase-related protein 2, DHPRP2, DRP-2, Dpysl2, Turned on after division 64 kDa protein, TOAD-64, Ulip2, Unc-33-like phosphoprotein 2
Description: Collapsin response mediator protein 2 (CRMP-2, DRP-2), is a kinesin-binding protein and a member of the CRMP family, a novel family of microtubule-associated proteins (MAPs). This family consists of 5 highly conserved phosphorylated proteins: CRMP1-CRMP5. CRMP-2 was originally identified in the regulation of microtubule dimerization. CRMP-2 is the first member of the CRMP family identified in primary neuronal cells1,2.Physiological functions of CRMP-2 protein include regulation of cell surface receptor endocytosis, kinesin-dependent axonal transport, growth cone collapse, polarity and differentiation of developing neurons and neurite outgrowth and the regulation of microtubule dynamics2.Studies suggest that CRMP-2 can modulate neuronal viability through the PI3K/mTOR/S6K pathway. In addition, CRMP-2 expression has been detected in non-neuronal cells such as leukocytes, fibroblasts and neuroblastoma1.Phosphorylation of CRMP-2 on specific Thr and Ser residues inactivates its activity, leading to inhibition of axonal growth and neuronal polarity. Knockdown of CRMP-2 shortens the total dendritic length and decreases dendritic branching3.
-
基因ID
- 25416
-
UniProt
- P47942
-
途径
- Regulation of Cell Size
抗原
-
