CNTF Receptor alpha 抗体 (Extracellular)
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Quick Overview for CNTF Receptor alpha 抗体 (Extracellular) (ABIN7884884)
抗原
See all CNTF Receptor alpha (CNTFR) 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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抗原表位
- AA 164-178, Extracellular
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原理
- A Rabbit Polyclonal Antibody to CNTF Receptor α
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预测反应
- Mouse,human - identical
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- CHIRYMHLFSTIKYK, corresponding to amino acid residues 164-178 of rat CNTFRalpha
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亚型
- IgG
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anti-Ciliary Neurotrophic Factor Receptor (CNTFR) (AA 106-342) antibody
CNTFR 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Ciliary Neurotrophic Factor Receptor (CNTFR) (AA 190-340) antibodyCNTFR 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Ciliary Neurotrophic Factor Receptor (CNTFR) (AA 151-160) antibodyCNTFR 适用: 人 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Ciliary Neurotrophic Factor Receptor (CNTFR) (AA 120-358) antibodyCNTFR 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ciliary Neurotrophic Factor Receptor (CNTFR) (AA 47-158) antibodyCNTFR 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Ciliary Neurotrophic Factor Receptor (CNTFR) (AA 295-344) antibodyCNTFR 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Ciliary Neurotrophic Factor Receptor (CNTFR) (Internal Region) antibodyCNTFR 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ciliary Neurotrophic Factor Receptor (CNTFR) (AA 164-178), (Extracellular) antibodyCNTFR 适用: 大鼠 WB, IHC, IF, FACS, LCI 宿主: 兔 Polyclonal unconjugated
anti-Ciliary Neurotrophic Factor Receptor (CNTFR) (Internal Region) antibodyVerified CNTFR 适用: 小鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Ciliary Neurotrophic Factor Receptor (CNTFR) (C-Term) antibodyCNTFR 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200
FC: 5 μg per reaction
ICC: The optimal concentration should be determined by the user
IHC: 1:400
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7235141)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW)
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存液
- Without preservative
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- CNTF Receptor alpha (CNTFR) (Ciliary Neurotrophic Factor Receptor (CNTFR))
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别名
- Ciliary neurotrophic factor receptor subunit alpha
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背景
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Synonyms: Ciliary neurotrophic factor receptor subunit alpha, CNTF receptor alpha, CNTFR alpha
Description: CNTF is a polypeptide trophic factor, member of the alpha-helical cytokine superfamily1. It was initially purified from the chick eye on the basis of its ability to promote survival of E8 chick ciliary ganglion neurons in culture2. CNTF is synthesized by glia both in the CNS and PNS3 and it has been demonstrated that CNTF is ubiquitously distributed in neurons and glia throughout the rodent brain4. CNTF effects are mediated by a tripartite receptor complex consisting of two signal-transducing subunits (leukemia inhibitory factor receptor, gp130) and a CNTF-specific ligand-binding-subunit (CNTFRα)5.CNTFRα is anchored to the membrane by a glycosyl-phosphatidylinositol (GPI) linkage and lacks the intracellular signaling moiety. It can be cleaved from the GPI anchor to yield a soluble form of the receptor (sCNTFRα)6,7.CNTF binds to CNTFRα, the latter associates with gp130 which recruits LIFR. This leads to the activation of a signaling cascade involving the JAK/STAT pathway7.CNTFRα knockout mice die within 24 hours after birth as opposed to CNTF knock animals which are viable. This strongly suggest that CNTFRα has other ligands besides CNTF. Indeed, CLC/CLF complex (cardiotrophin like cytokine/cytokine-like factor-1) binds CNTFRα and activates a similar signaling pathway to that of CNTF8.
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基因ID
- 313173
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UniProt
- Q08406
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途径
- JAK/STAT Signaling, Feeding Behaviour
抗原
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