CLCNKA 抗体 (C-Term, Intracellular)
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Quick Overview for CLCNKA 抗体 (C-Term, Intracellular) (ABIN7884876)
抗原
See all CLCNKA 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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抗原表位
- AA 674-687, C-Term, Intracellular
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原理
- A Rabbit Polyclonal Antibody to CLC-K Channel
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预测反应
- Mouse - identical, human - 13,14 amino acid residues identical
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)KKAISTLTNPPAPK, corresponding to amino acid residues 674-687 of the rat longer form CLC-K2L
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亚型
- IgG
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anti-Chloride Channel Ka (CLCNKA) (C-Term) antibody
CLCNKA 适用: 人 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Chloride Channel Ka (CLCNKA) (C-Term) antibodyCLCNKA 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Chloride Channel Ka (CLCNKA) (AA 470-644) antibodyCLCNKA 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Chloride Channel Ka (CLCNKA) (N-Term) antibodyCLCNKA 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Chloride Channel Ka (CLCNKA) antibodyCLCNKA 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Chloride Channel Ka (CLCNKA) (AA 20-47), (N-Term) antibodyCLCNKA 适用: 人 WB 宿主: 兔 Polyclonal RB37056 unconjugated
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应用备注
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WB: 1:200
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: The optimal concentration should be determined by the user
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7235094)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW)
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存液
- Without preservative
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- CLCNKA (Chloride Channel Ka (CLCNKA))
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别名
- CLC-K1
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背景
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Synonyms: CLC-K1, CLC-K2, CLC-Ka, CLC-Kb, Clcnka, Clcnkb, ClCk, Chloride channel K
Description: CLC-Ka and CLC-Kb are members of the voltage-dependent Cl- channel (CLC) family that includes nine known members in mammals. The human CLC-Ka and CLC-Kb (known as CLC-K1 and CLC-K2 in the rat) channels are closely related genes that share 94 % sequence homology and identical genomic organization.CLC channels can be classified as plasma membrane channels and intracellular organelle channels. The first group includes the CLC-1, CLC-2, CLC-Ka and CLC-Kb channels. The second group comprises the CLC-3, CLC-4, CLC-5, CLC-6 and CLC-7.CLC channels that function in the plasma membrane are involved in the stabilization of membrane potential and in transepithelial transport. The presumed function of the intracellular CLC channels is support of the acidification of the intraorganellar compartment. In this regard, recent reports indicate that CLC-4 and CLC-5 (and by inference CLC-3) can function as Cl-/H+ antiporters.1, 2The functional unit of the CLC channels is a dimer with each subunit forming a proper pore. Although the crystal structure of bacterial CLC channels was resolved,the topology of the CLC channels is complex and has not been fully elucidated. It is generally accepted that both the N- and C- terminus domains are intracellular while the number and configuration of the transmembrane domains vary greatly between different models. 1,2CLC-K channels require the presence of the auxiliary b subunit barttin, a 34 kD transmembrane protein, for transport to the plama membrane and regulation of channel permeation and gating.3CLC-K channels are expressed primarily in the kidney from the thin ascending limb to the collecting duct of the nephron, and in the stria vascularis and dark cells of the vestibular organ of the inner ear.The channels are important for renal salt reabsorption and water balance by enabling chloride exit across the basolateral membranes. The importance of the CLC-K channel in renal function is demonstrated by the fact that loss-of-function mutations in CLC-Kb lead to Bartter syndrome type III, an autosomal recessive disorder characterized by severe salt wasting, low blood pressure, hypokalemia and hypercalciuria.4
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基因ID
- 79430
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UniProt
- P51802
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途径
- Response to Water Deprivation
抗原
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