Calcitonin Receptor 抗体 (1st Extracellular Loop)
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Quick Overview for Calcitonin Receptor 抗体 (1st Extracellular Loop) (ABIN7884806)
抗原
See all Calcitonin Receptor (CALCR) 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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抗原表位
- 1st Extracellular Loop, AA 201-215
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原理
- A Rabbit Polyclonal Antibody to Calcitonin Receptor
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预测反应
- Mouse - identical, human - 14,15 amino acid residues identical
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)HLVEVVPNGDLVRRD, corresponding to amino acid residues 201-215 of rat CALCR
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亚型
- IgG
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anti-Calcitonin Receptor (CALCR) (AA 42-170) antibody
CALCR 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Calcitonin Receptor (CALCR) (C-Term) antibodyCALCR 适用: 人 IHC, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Calcitonin Receptor (CALCR) (N-Term) antibodyCALCR 适用: 人, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Calcitonin Receptor (CALCR) (AA 394-474) antibodyCALCR 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2F7 unconjugated
anti-Calcitonin Receptor (CALCR) (AA 465-494) antibodyCALCR 适用: 人 WB, IF, FACS 宿主: 兔 Polyclonal RB22504 unconjugated
anti-Calcitonin Receptor (CALCR) (AA 31-120) antibodyCALCR 适用: 大鼠, 小鼠 ELISA, IF (cc), IF (p), ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Calcitonin Receptor (CALCR) (AA 34-148) antibodyCALCR 适用: 大鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Calcitonin Receptor (CALCR) (AA 445-474) antibodyCALCR 适用: 人 WB, IHC, IF, FACS, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Calcitonin Receptor (CALCR) (AA 1-474) antibodyCALCR 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Calcitonin Receptor (CALCR) (AA 25-148) antibodyCALCR 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200
FC: The optimal concentration should be determined by the user
ICC: 1:50
IHC: The optimal concentration should be determined by the user
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7234900)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW)
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存液
- Without preservative
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- Calcitonin Receptor (CALCR)
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别名
- CALCR
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背景
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Synonyms: CALCR, CT receptor, CT-R, C1A/C1B
Description: the calcitonin receptor (CTR) is a class B G-protein coupled receptor (GPCR) that signals via activation of cAMP and protein kinase C (PKC). It is one of 15 human class B GPCRs1,2. Apart from CTR, calcitonin receptor-like receptor (CTLR) is the only other B-class GPCR to bind calcitonin. To date, there are three known human CTR mRNA isoforms arising from alternative splicing3.Calcitonin itself is a peptide hormone that contributes to bone calcification by direct inhibition of osteoclasts which resorb the bony tissue. It is part of a six-member family that has varied functionalities. By binding to receptor activity modifying proteins (RAMPs), CTR and CTLR can form receptors to every member of the calcitonin family. For instance, RAMP1 and CTR construct the calcitonin gene-related peptide (CGRP) receptor.Both CTR and CTLR have seven transmembrane domains, an intracellular C-terminal, and an extracellular N-terminal. To activate the receptors, their N-terminal must first capture the C-terminal of the ligand and then carried to the transmembrane loops where it bestows a conformational change upon them.Besides the bone, CTR has prominent roles in the kidney, CNS, placenta, ovaries, sperm, lung, and in the brain4,5.In osteoclasts, the expression of CTRs declines with age. Interestingly, polymorphism of the CTR gene is strongly associated with decreased fracture-risk in post-menopausal women3,6.
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基因ID
- 116506
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UniProt
- P32214
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途径
- cAMP Metabolic Process
抗原
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