Cadherin 13 抗体 (Extracellular, N-Term)
Our Local Distributor
北京 101111
Quick Overview for Cadherin 13 抗体 (Extracellular, N-Term) (ABIN7884804)
抗原
See all Cadherin 13 (CDH13) 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
-
-
抗原表位
- AA 164-178, Extracellular, N-Term
-
原理
- A rabbit polyclonal antibody to Cadherin-13 (extracellular)
-
预测反应
- Rat - identical. Human - 14 out of 15 amino acid residues identical.
-
纯化方法
- Affinity purified on immobilized antigen.
-
免疫原
- (C)DSDRPEGSKFRLTGK, corresponding to amino acid residues 164 - 178 of mouse CDH13
-
亚型
- IgG
-
-
anti-Cadherin 13 (CDH13) (AA 23-133) antibody
CDH13 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cadherin 13 (CDH13) (AA 1-713) antibodyCDH13 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Cadherin 13 (CDH13) (AA 301-400) antibodyCDH13 适用: 人 ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Cadherin 13 (CDH13) (AA 1-713) antibodyCDH13 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Cadherin 13 (CDH13) (AA 149-692) antibodyCDH13 适用: 人, 大鼠 WB, IHC, ELISA, ICC, IF, FACS 宿主: 兔 Polyclonal unconjugated
anti-Cadherin 13 (CDH13) (AA 478-690) antibodyCDH13 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cadherin 13 (CDH13) (AA 179-366) antibodyCDH13 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cadherin 13 (CDH13) (AA 589-617), (C-Term) antibodyCDH13 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cadherin 13 (CDH13) (AA 146-174), (N-Term) antibodyCDH13 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cadherin 13 (CDH13) (AA 222-256) antibodyCDH13 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB48597 unconjugated
-
-
应用备注
- The optimal concentration should be determined by the user
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- 0.2 mL double distilled water (DDW).
-
浓度
- 1 mg/mL
-
缓冲液
- PBS pH 7.4
-
储存液
- Without preservative
-
储存条件
- -20 °C
-
储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
-
-
- Cadherin 13 (CDH13)
-
别名
- CDH13
-
背景
-
Synonyms: CDH13, Heart Cadherin, H-Cadherin, Truncated Cadherin, T-Cadherin, T-Cad
Description:
Cadherin-13 (CDH13), also known as Heart Cadherin (H-Cadherin) or Truncated Cadherin (T-cadherin), is a member of the cadherin superfamily, a group of calcium-dependent cell adhesion molecules integral to various cellular processes, including tissue development and maintenance.1
Unlike classical cadherins, which are type I membrane proteins that span the cell membrane once, Cadherin-13 is anchored to the cell membrane by a glycosylphosphatidylinositol (GPI)-anchor, making it an atypical cadherin.1,2
Cadherin-13 is predominantly expressed in the nervous system, where it regulates neuronal migration, axon growth, and synaptic connectivity during brain development. It mediates cell adhesion through homophilic interactions, meaning it binds to other Cadherin-13 Molecules on adjacent cells. This adhesive property is crucial for maintaining the structural integrity of neural circuits and facilitating proper brain function.2,3
Alterations in Cadherin-13 expression or function have been linked to various neurodevelopmental and psychiatric disorders, including attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder, and schizophrenia. These associations underscore the critical role of Cadherin-13 in brain function and behavior.3,4
Beyond the nervous system, Cadherin-13 has been implicated in metabolic regulation. It serves as a binding protein for high molecular weight isoforms of adiponectin, an adipose-derived hormone with anti-inflammatory and insulin-sensitizing properties. This interaction is essential for mediating adiponectin's effects on metabolic processes and vascular function.3,5,6
Finally, Cadherin-13 expression is often downregulated in various cancers, including colon and prostate cancers. This downregulation is associated with increased invasive and metastatic potential of tumor cells and poorer prognosis, indicating that Cadherin-13 may function as a tumor suppressor.7
-
基因ID
- 12554
-
UniProt
- Q9WTR5
-
途径
- EGFR Signaling Pathway, Cell-Cell Junction Organization
抗原
-
