Anoctamin 2 抗体 (3rd Extracellular Loop)
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Quick Overview for Anoctamin 2 抗体 (3rd Extracellular Loop) (ABIN7884759)
抗原
See all Anoctamin 2 (ANO2) 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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抗原表位
- 3rd Extracellular Loop, AA 632-646
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原理
- A Rabbit Polyclonal Antibody to Anoctamin-2 (TMEM16B) Channel
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预测反应
- human - 13,Rat - 14,15 amino acid residues identical
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)HSKRPEQWDLDHSLE, corresponding to amino acid residues 632-646 of mouse Anoctamin-2
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亚型
- IgG
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anti-Anoctamin 2 (ANO2) (AA 1-83) antibody
ANO2 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Anoctamin 2 (ANO2) (AA 1-200) antibodyANO2 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Anoctamin 2 (ANO2) (AA 823-1003) antibodyANO2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Anoctamin 2 (ANO2) (3rd Extracellular Loop), (AA 632-646) antibodyKO Validated ANO2 适用: 小鼠 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: 1:200
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7234739)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW)
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存液
- Without preservative
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- Anoctamin 2 (ANO2)
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别名
- Anoctamin-2
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背景
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Synonyms: Anoctamin-2, Transmembrane protein 16B, C12orf3
Description: Anoctamin (ANO or TMEM16) is a family of 10 membrane proteins. This family is named so because these channels are selective to ANions and have eight (OCT) transmembrane domains. Also, these channels are subject to glycosylation in their extracellular loops and have both intracellular N- and C-termini1. Members of this family are expressed in a broad range of different organisms ranging from mammals, flies, worms, plants and yeast1. Alternative splicing is known to affect these channels and regarding their oligomerization state, homedimerization has been observed although when heterologously expressed, these channels may hetero oligomerize2.Ano1 (or TMEM16A, DOG1 and others) the first member to be identified was found to be a Ca2+-activated Cl- channel3-5 therefore other members are likely to also be Cl- channels. These channels are expressed in many different tissues: bronchiolar epithelial cells, pancreatic acinar cells, proximal kidney tubule epithelium, retina, dorsal root ganglia and submandibular gland1. In fact, Ano1 gained a lot of attention as its activation may serve as a therapeutic treatment for cystic fibrosis since it is also expressed in the airways6. These Ca2+-activated Cl- channels are believed to play a role in development as knockout of Ano1 in mice causes abnormal development of the trachea7. Ano2 (TMEM16B) has been shown to mediate Ca2+-activated Cl- current in olfactory epithelium and photoreceptor synapses2,8,9.Although relatively newly discovered channels, they are being discovered in many medical indications. Ano1 has become a marker in gastrointestinal tumors as its expression is significantly upregulated10,11. Similarly, Ano1 is also highly expressed in other carcinomas12,13.
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基因ID
- 243634
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UniProt
- Q8CFW1
抗原
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