ADRA2A 抗体 (Extracellular, N-Term)
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Quick Overview for ADRA2A 抗体 (Extracellular, N-Term) (ABIN7884749)
抗原
See all ADRA2A 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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抗原表位
- AA 7-20, Extracellular, N-Term
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原理
- A Rabbit Polyclonal Antibody to α2A-Adrenergic Receptor
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预测反应
- Mouse - identical, human - 13,14 amino acid residues identical
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)DAGNSSWNGTEAPG, corresponding to amino acid residues 7-20 of rat alpha2A-adrenoceptor
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亚型
- IgG
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anti-Alpha-2A Adrenergic Receptor (ADRA2A) (AA 385-450) antibody
ADRA2A 适用: 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Alpha-2A Adrenergic Receptor (ADRA2A) (Internal Region) antibodyADRA2A 适用: 人, 大鼠, 小鼠 WB, ELISA, IF, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Alpha-2A Adrenergic Receptor (ADRA2A) (AA 240-380) antibodyADRA2A 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Alpha-2A Adrenergic Receptor (ADRA2A) (AA 7-20), (Extracellular), (N-Term) antibodyADRA2A 适用: 大鼠 WB, IF, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Alpha-2A Adrenergic Receptor (ADRA2A) (Internal Region) antibodyVerified ADRA2A 适用: 人 ELISA, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Alpha-2A Adrenergic Receptor (ADRA2A) (AA 331-380) antibodyADRA2A 适用: 人, 大鼠, 小鼠 WB, ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-Alpha-2A Adrenergic Receptor (ADRA2A) (AA 118-152) antibodyADRA2A 适用: 人 WB 宿主: 兔 Polyclonal RB53330 unconjugated
anti-Alpha-2A Adrenergic Receptor (ADRA2A) (AA 223-256) antibodyADRA2A 适用: 斑马鱼 WB 宿主: 兔 Polyclonal RB52053 unconjugated
anti-Alpha-2A Adrenergic Receptor (ADRA2A) (C-Term) antibodyADRA2A 适用: 人, 大鼠, 小鼠 WB, ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-Alpha-2A Adrenergic Receptor (ADRA2A) (AA 218-374) antibodyADRA2A 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200
FC: 5 μg per reaction
ICC: The optimal concentration should be determined by the user
IHC: 1:250
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7234696)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW)
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存液
- Without preservative
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- ADRA2A (Alpha-2A Adrenergic Receptor (ADRA2A))
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别名
- Alpha-2A adrenoceptor
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背景
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Synonyms: Alpha-2A adrenoceptor, Alpha-2D adrenergic Receptor, α-2AAR, ADA2A, ADRA2A
Description: Adrenergic receptors (also called adrenoceptors) are the receptors for the catecholamines adrenaline and noradrenaline (called epinephrine and norepinephrine in the United States). Adrenaline and noradrenaline play important roles in the control of blood pressure, myocardial contractile rate and force, airway reactivity, and a variety of metabolic and central nervous system functions. Adrenergic receptors are members of the G-protein coupled receptor (GPCR) superfamily of membrane proteins. They share a common structure of seven putative transmembrane domains, an extracellular N-terminus, and a cytoplasmic C- terminus.Adrenoceptors are divided into three types: α1, α2 and β-adrenoceptors. Each type is further divided into at least three subtypes: α1A, α1B, α1D, α2A, α2B, α2C, β1, β2, β31,2. Adrenoceptors are expressed in nearly all peripheral tissues and in the central nervous system1,2. In general, the pharmacological properties of each subtype are quite homogenous across different species. However, this is not the case for the α2A subtype which was first isolated from human platelets3. This subtype shows different pharmacological properties from that of mouse and rat. For this reason, until molecular techniques significantly advanced, it was believed that human α2A and that of mouse and rat (termed α2D) were two different subtypes. Today, it is accepted that these two subtypes are in fact one gene product and is generally termed α2A. One of the main differences between this subtype from the different organisms is its affinity for yohimbine and rauwolscine, rat and mouse α2A displays less affinity compared to human3,4.
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基因ID
- 25083
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UniProt
- P22909
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途径
- EGFR Signaling Pathway, Negative Regulation of Hormone Secretion, Carbohydrate Homeostasis, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Negative Regulation of Transporter Activity
抗原
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