Aggrecan 抗体 (Intracellular, N-Term)
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Quick Overview for Aggrecan 抗体 (Intracellular, N-Term) (ABIN7884748)
抗原
See all Aggrecan (ACAN) 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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抗原表位
- AA 169-181, Intracellular, N-Term
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原理
- A Rabbit Polyclonal Antibody to SLC25A12
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预测反应
- Rat,human - identical
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)KDKSKSGMISGLD, corresponding to amino acid residues 169-181 of mouse SLC25A12
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亚型
- IgG
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anti-Aggrecan (ACAN) (AA 101-220) antibody
ACAN 适用: 人, 大鼠, 小鼠, 兔 WB, ELISA, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Aggrecan (ACAN) (AA 34-147) antibodyACAN 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Aggrecan (ACAN) (AA 34-147) antibodyACAN 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Aggrecan (ACAN) (AA 56-155) antibodyACAN 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2A8 unconjugated
anti-Aggrecan (ACAN) antibodyACAN 适用: 人 WB, IF (p), FACS 宿主: 兔 Monoclonal 24GB3415 unconjugated Recombinant Antibody
anti-Aggrecan (ACAN) (AA 601-700) antibodyACAN 适用: 大鼠, 小鼠, 兔 ICC, ELISA, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Aggrecan (ACAN) (N-Term) antibodyACAN 适用: 人, 大鼠, 小鼠 WB, IHC, ICC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Aggrecan (ACAN) (C-Term) antibodyACAN 适用: 人, 大鼠, Hamster, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Aggrecan (ACAN) (AA 587-684) antibodyACAN 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Aggrecan (ACAN) (AA 2066-2316) antibodyACAN 适用: Cow WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: 1:200
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7237025)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW)
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存液
- Without preservative
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- Aggrecan (ACAN)
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别名
- AGC1
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背景
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Synonyms: AGC1, ARALAR1, Solute carrier family 25 member 12, Mitochondrial aspartate glutamate carrier 1, Calcium-binding mitochondrial carrier protein Aralar1, Araceli hiperlarga
Description: SLC25 is a large family of nuclear-encoded transporters embedded in the inner mitochondrial membrane and in a few cases other organelle membranes.SLC2512A is a gene encoding the aspartate/glutamate carrier 1 (AGC1). AGC1 possesses six transmembrane alpha helices and N- and C-termini on the cytosolic side of the membrane1.AGC1 catalyzes an exchange between intra-mitochondrial aspartate and cytosolic glutamate, an important step in urea synthesis. As a component of the malate-aspartate shuttle (MAS), AGC1 also has a role in the transfer of NADH, carrying reducing equivalents from the cytosol into the mitochondrial matrix. AGC1 is expressed predominantly in heart and skeletal muscle, with weaker expression in brain and kidney. AGC1 is the main AGC isoform present in the adult brain, and it is expressed mainly in neurons. As part of the MAS, AGC1 has a role in the physiology of pancreatic β-cells by influencing glucose-induced activation of mitochondrial metabolism and insulin secretion and it is the only AGC isoform expressed in pancreatic islets and β-cells. AGC1 has several Ca2+-binding EF-hand motifs located on its long, hydrophilic amino-terminus which extends into the intermembrane space and its activity is strongly regulated by extra-mitochondrial Ca2+. Dysregulation of cellular Ca2+ homeostasis mediated by AGC1 has been implicated in the pathogenesis of autistic spectrum disorder2.
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基因ID
- 78830
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UniProt
- Q8BH59
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途径
- Glycosaminoglycan Metabolic Process, Dicarboxylic Acid Transport
抗原
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