ADCY3 抗体 (3rd Extracellular Loop)
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Quick Overview for ADCY3 抗体 (3rd Extracellular Loop) (ABIN7884730)
抗原
See all ADCY3 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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抗原表位
- 3rd Extracellular Loop, AA 285-299
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原理
- A Rabbit Polyclonal Antibody to Adenylate Cyclase Type III
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预测反应
- Mouse,human - identical
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)KHVADEMLKDMKKDE, corresponding to amino acid residues 285-299 of rat ADCY3
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亚型
- IgG
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anti-Adenylate Cyclase 3 (ADCY3) (AA 501-736) antibody
ADCY3 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Adenylate Cyclase 3 (ADCY3) antibodyADCY3 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Adenylate Cyclase 3 (ADCY3) (3rd Extracellular Loop), (AA 285-299) antibodyADCY3 适用: 大鼠 WB, IHC, IF, FACS, IC, LCI 宿主: 兔 Polyclonal unconjugated
anti-Adenylate Cyclase 3 (ADCY3) (C-Term) antibodyADCY3 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Adenylate Cyclase 3 (ADCY3) (AA 651-750) antibodyADCY3 适用: 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Adenylate Cyclase 3 (ADCY3) (AA 1125-1144) antibodyADCY3 适用: 大鼠, 小鼠 WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Adenylate Cyclase 3 (ADCY3) (3rd Extracellular Loop), (AA 285-299) antibody (Atto 488)ADCY3 适用: 大鼠 IF, FACS, IC, LCI 宿主: 兔 Polyclonal Atto 488
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应用备注
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WB: 1:200
FC: 2.5 μg per reaction
ICC: 1:50
IHC: 1:400
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7234646)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW)
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存液
- Without preservative
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- ADCY3 (Adenylate Cyclase 3 (ADCY3))
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别名
- Adenylate cyclase type 3
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背景
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Synonyms: Adenylate cyclase type 3, Adenylate cyclase type III, AC-III, ATP pyrophosphate-lyase 3, Adenylate cyclase olfactive type, Adenylyl cyclase 3, ADCY3
Description: Adenylyl cyclases (ACs) are a family of enzymes that synthesize cAMP, upon stimulation. cAMP is an important second messenger, which regulates carbohydrate, lipid, protein, and nucleic acid metabolism as well as synaptic transmission, ion channel function, and transcription in neurons1. There are nine closely related isoforms of ACs (AC1-9) in mammals. All AC isoforms share a primary structure consisting of two hydrophobic regions which comprise six transmembrane helices and three large cytoplasmic domains. The basic catalytic unit of a membrane-bound AC molecule consists of the C1a and C2 domains. The N-terminus domains of ACs are highly variable, and might play a regulatory role2.Adenylyl cyclase type 3 (AC3) is widely expressed in the olfactory tissue, human cell line HEK-293, bovine brain, spinal cord, adrenal medulla, adrenal cortex, heart atrium, aorta, lung and retina3.Several studies have suggested that AC3 may play an important role in the regulation of glucose metabolism and body weight. It was found that overexpression of AC3 mRNA is involved in pathophysiological metabolic processes, such as type 2 diabetes4. In addition, a recent study demonstrated the association of AC3 with gastric cancer as well as its tumorigenic potentials5.Furthermore, AC3-knockout mice showed peripheral and behavioral anosmia6.
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基因ID
- 64508
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UniProt
- P21932
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途径
- EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Thyroid Hormone Synthesis, cAMP Metabolic Process, Myometrial Relaxation and Contraction, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma
抗原
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