ADAM22 抗体 (Extracellular, N-Term)
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Quick Overview for ADAM22 抗体 (Extracellular, N-Term) (ABIN7884717)
抗原
See all ADAM22 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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抗原表位
- AA 715-729, Extracellular, N-Term
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原理
- A Rabbit Polyclonal Antibody to ADAM22
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预测反应
- Rat,human - identical
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)HNDDAKTGITLSGNG, corresponding to amino acid residues 715-729 of mouse ADAM22
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亚型
- IgG
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anti-ADAM Metallopeptidase Domain 22 (ADAM22) (AA 223-829) antibody
ADAM22 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
anti-ADAM Metallopeptidase Domain 22 (ADAM22) (AA 370-582) antibodyADAM22 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-ADAM Metallopeptidase Domain 22 (ADAM22) (AA 1-342) antibodyADAM22 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-ADAM Metallopeptidase Domain 22 (ADAM22) (AA 298-347) antibodyADAM22 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 兔, Bat, 猴, Pig, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-ADAM Metallopeptidase Domain 22 (ADAM22) (AA 223-400) antibodyADAM22 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-ADAM Metallopeptidase Domain 22 (ADAM22) (N-Term) antibodyADAM22 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-ADAM Metallopeptidase Domain 22 (ADAM22) (AA 775-905) antibodyADAM22 适用: 小鼠, 大鼠 WB, IHC, ICC 宿主: 豚鼠 Polyclonal unconjugated
anti-ADAM Metallopeptidase Domain 22 (ADAM22) (AA 715-729), (Extracellular), (N-Term) antibodyADAM22 适用: 小鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: 1:200
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7234619)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW)
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存液
- Without preservative
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- ADAM22 (ADAM Metallopeptidase Domain 22 (ADAM22))
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别名
- Disintegrin and metalloproteinase domain-containing protein 22
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背景
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Synonyms: Disintegrin and metalloproteinase domain-containing protein 22, ADAM metallopeptidase domain 22, MDC2
Description: ADAMs (a disintegrin and metalloproteinases) are multi-domain transmembrane glycoproteins with diverse roles in physiology and disease. Notably, 8 of 21 ADAMs lack functional metalloproteinase domains and are implicated in protein-protein interactions instead of membrane protein ectodomain shedding.ADAM22 is a non-proteinase which acts as a post synaptic receptor for the secreted neurotransmission modulator LGI-1 at neural synapses. ADAM22 is a compact four-leaf clover with the metalloproteinase-like domain (Domain M) held in the concave face of a rigid module formed by the disintegrin (Domain D), cysteine-rich (Domain C), and epidermal growth factor-like domains (Domain E). The largest domain in the four-leaf clover, domain M, is distal to the cell membrane. Following domain M, domain D and domain C zigzag to domain E in a compact, but not extended fashion. A 15-amino acid linker, leads the C terminus of domain E to the membrane. The loss of metalloproteinase activity is ensured by the absence of critical catalytic residues, the filling of the substrate groove, and the steric hindrance by the cysteine-rich domain. The extracellular domain of ADAM22 interacts with LGI-1, whereas its cytoplasmic PDZ-binding motif recruits PSD-95. The link of ADAM22 and LGI-1 to AMPA receptors establishes their roles in glutamate neurotransmission1.Mutations that impair LGI-1 binding to ADAM22 are implicated in the pathogenesis of Autosomal dominant lateral temporal epilepsy (ADTLE), a focal epilepsy syndrome characterized by focal seizures with prominent auditory or aphasic symptoms, normal magnetic resonance imaging, and usually benign evolution2.
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基因ID
- 11496
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UniProt
- Q9R1V6
抗原
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