Vitronectin Receptor 抗体
The 小鼠 单克隆 anti-Vitronectin Receptor antibody (Clone 23C6) (ABIN7882688) specifically detects Vitronectin Receptor in ELISA.
The antibody is reactive with 人 samples.
产品编号 ABIN7882688
发货至:
中国
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Quick Overview for Vitronectin Receptor 抗体 (ABIN7882688)
抗原
Vitronectin Receptor
适用
人
宿主
小鼠
克隆类型
单克隆
标记
非结合性
应用范围
ELISA
克隆位点
23C6
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原理
- Vitronectin Receptor Antibody / Integrin alpha V / ITGAV
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纯化方法
- Protein G affinity chromatography
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免疫原
- Osteoclasts from osteoclastomas were used as the immunogen for the Vitronectin Receptor antibody.
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亚型
- IgG1, kappa
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应用备注
- Optimal dilution of the Vitronectin Receptor antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.2 mg/mL
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缓冲液
- 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store the Vitronectin Receptor antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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- Vitronectin Receptor
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背景
- ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8, 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands, the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin Receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction. Alternative splicing results in multiple transcript variants. Reacts with Integrin Alpha V Beta 3. 23C6 may be useful for bone resorption modulation, osteoclast identification, receptor purification, malignant melanoma identification and treatment.
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UniProt
- P06756
抗原
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