Vitamin D Receptor 抗体
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Quick Overview for Vitamin D Receptor 抗体 (ABIN7882684)
抗原
See all Vitamin D Receptor (VDR) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Vitamin D Receptor Antibody / VDR
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纯化方法
- Affinity purified
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免疫原
- A synthetic peptide specific to human Vitamin D Receptor / VDR was used as the immunogen for the Vitamin D Receptor antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the Vitamin D Receptor antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Antibody in PBS with 0.02 % sodium azide, 50 % glycerol and 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the Vitamin D Receptor antibody at -20oC.
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- Vitamin D Receptor (VDR)
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别名
- Vitamin D Receptor
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物质类
- Chemical
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背景
- The VDR gene encodes vitamin D3 receptor, which is a member of the nuclear hormone receptor superfamily of ligand-inducible transcription factors. This receptor also functions as a receptor for the secondary bile acid, lithocholic acid. Downstream targets of vitamin D3 receptor are principally involved in mineral metabolism, though this receptor regulates a variety of other metabolic pathways, such as those involved in immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [RefSeq]
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UniProt
- P11473
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途径
- Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway
抗原
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