Recombinant UBA7 抗体
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北京 101111
Quick Overview for Recombinant UBA7 抗体 (ABIN7882633)
抗原
See all UBA7 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- UBA7 Antibody / Ubiquitin like modifier activating enzyme 7 / Ube1L
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纯化方法
- Affinity-chromatography
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免疫原
- A synthesized peptide derived from human Ube1L / UBA7 was used as the immunogen for the UBA7 antibody.
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亚型
- IgG
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anti-Ubiquitin-Like Modifier Activating Enzyme 7 (UBA7) (AA 429-488) antibody
UBA7 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin-Like Modifier Activating Enzyme 7 (UBA7) (AA 1-1012) antibodyUBA7 适用: 人 WB, IP, IF 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin-Like Modifier Activating Enzyme 7 (UBA7) (C-Term) antibodyUBA7 适用: 人 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin-Like Modifier Activating Enzyme 7 (UBA7) (AA 1-1012) antibodyUBA7 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Ubiquitin-Like Modifier Activating Enzyme 7 (UBA7) (C-Term) antibodyUBA7 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin-Like Modifier Activating Enzyme 7 (UBA7) (AA 1-1012) antibodyUBA7 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Ubiquitin-Like Modifier Activating Enzyme 7 (UBA7) antibodyUBA7 适用: 人 WB, FACS 宿主: 兔 Monoclonal 24GB2660 unconjugated Recombinant Antibody
anti-Ubiquitin-Like Modifier Activating Enzyme 7 (UBA7) (N-Term) antibodyUBA7 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin-Like Modifier Activating Enzyme 7 (UBA7) antibodyUBA7 适用: 人 WB, FACS 宿主: 兔 Monoclonal 25GB1770 unconjugated Recombinant Antibody
anti-Ubiquitin-Like Modifier Activating Enzyme 7 (UBA7) antibodyUBA7 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the UBA7 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the UBA7 antibody at -20oC.
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- UBA7 (Ubiquitin-Like Modifier Activating Enzyme 7 (UBA7))
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别名
- UBA7
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背景
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UBA7 antibody detects ubiquitin like modifier activating enzyme 7, an E1 enzyme encoded by the UBA7 gene. UBA7 catalyzes the first step in the ISGylation pathway, activating the ubiquitin like modifier ISG15. This modification resembles ubiquitination but involves the conjugation of ISG15 to target proteins, regulating antiviral responses, immune signaling, and protein stability. By activating ISG15, UBA7 plays a central role in interferon stimulated gene expression and innate immunity.
UBA7 antibody is widely applied in immunology, virology, and cancer biology. UBA7 is induced by type I interferons and mediates host defense against viral infection. ISGylation of viral and host proteins disrupts replication cycles and enhances antiviral resistance. By detecting UBA7, researchers can investigate how interferon pathways regulate protein modification and innate immunity.
Western blot assays detect UBA7 protein in interferon treated cells, while immunohistochemistry maps its expression in immune tissues. Immunofluorescence highlights cytoplasmic and nuclear localization, consistent with its role in protein conjugation. These applications make UBA7 antibody a versatile tool for studying antiviral responses and immune regulation.
Beyond virology, UBA7 contributes to tumor suppression. Loss of UBA7 expression has been linked to lung cancer and leukemia, where reduced ISGylation disrupts normal cell regulation. UBA7 also interacts with ubiquitin conjugating enzymes, linking ISGylation to broader protein quality control mechanisms. By applying UBA7 antibody, scientists can evaluate how ubiquitin like modifications influence cancer biology and immune defense.
UBA7 antibody from NSJ Bioreagents provides dependable specificity for analyzing ISGylation pathways. Its strong performance across applications supports both basic and translational research into immune signaling, antiviral defense, and cancer suppression. -
UniProt
- P41226
抗原
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