Recombinant TMEM67 抗体
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北京 101111
Quick Overview for Recombinant TMEM67 抗体 (ABIN7882553)
抗原
See all TMEM67 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- TMEM67 Antibody / Meckelin
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纯化方法
- Affinity-chromatography
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免疫原
- A synthesized peptide derived from human Meckelin was used as the immunogen for the TMEM67 antibody.
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亚型
- IgG
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anti-Transmembrane Protein 67 (TMEM67) (Internal Region) antibody
TMEM67 适用: 人, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Transmembrane Protein 67 (TMEM67) (AA 241-500) antibodyTMEM67 适用: 人 ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-Transmembrane Protein 67 (TMEM67) (C-Term) antibodyTMEM67 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Transmembrane Protein 67 (TMEM67) antibodyTMEM67 适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB4990 unconjugated Recombinant Antibody
anti-Transmembrane Protein 67 (TMEM67) (Center) antibodyTMEM67 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the TMEM67 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the TMEM67 antibody at -20oC.
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- TMEM67 (Transmembrane Protein 67 (TMEM67))
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别名
- TMEM67
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背景
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TMEM67 antibody detects meckelin, a transmembrane protein encoded by the TMEM67 gene. Meckelin localizes to primary cilia and the plasma membrane, where it contributes to ciliary structure and signaling. Mutations in TMEM67 cause Meckel syndrome type 3 and Joubert syndrome type 6, autosomal recessive ciliopathies characterized by developmental abnormalities, cystic kidneys, and neurological defects. Meckelin is therefore essential for cilia based signaling pathways, including Wnt and Hedgehog.
TMEM67 antibody is widely applied in developmental biology, nephrology, and neurogenetics. By detecting meckelin, researchers can study how ciliary proteins regulate organ development and signaling. Ciliary dysfunction underlies a spectrum of disorders known as ciliopathies, linking TMEM67 research to human disease mechanisms.
Western blot assays detect meckelin in tissue lysates, while immunohistochemistry maps expression in kidney, brain, and liver. Immunofluorescence highlights punctate staining at primary cilia, consistent with its functional localization. These applications provide robust tools for examining ciliary protein biology.
Meckelin plays roles in regulating planar cell polarity, neuronal migration, and renal morphogenesis. Its dysfunction disrupts signaling and tissue organization, causing developmental defects and organ pathology. By applying TMEM67 antibody, scientists can investigate pathways linking ciliary function to embryogenesis, neurodevelopment, and kidney disease.
TMEM67 antibody from NSJ Bioreagents delivers dependable specificity for studying meckelin function. Its strong performance ensures accurate detection across developmental and disease contexts. -
UniProt
- Q5HYA8
抗原
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