Recombinant SEC62 抗体
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北京 101111
Quick Overview for Recombinant SEC62 抗体 (ABIN7882545)
抗原
See all SEC62 (TLOC1) 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- SEC62 Antibody / Translocation protein SEC62
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纯化方法
- Affinity chromatography
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免疫原
- A synthesized peptide derived from human SEC62 was used as the immunogen for the SEC62 antibody.
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亚型
- IgG
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anti-Translocation Protein 1 (TLOC1) (AA 1-30), (N-Term) antibody
TLOC1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB32610 unconjugated
anti-Translocation Protein 1 (TLOC1) (AA 349-399) antibodyTLOC1 适用: 人, 小鼠 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Translocation Protein 1 (TLOC1) (C-Term) antibodyTLOC1 适用: 人, 小鼠, 大鼠 WB, IF, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Translocation Protein 1 (TLOC1) (AA 1-30), (N-Term) antibodyTLOC1 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the SEC62 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the SEC62 antibody at -20oC.
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- SEC62 (TLOC1) (Translocation Protein 1 (TLOC1))
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别名
- SEC62
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背景
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SEC62 antibody detects Translocation protein SEC62, encoded by the SEC62 gene. Translocation protein SEC62 is an endoplasmic reticulum membrane protein that functions as part of the SEC61-SEC62-SEC63 complex required for posttranslational translocation of proteins into the endoplasmic reticulum. SEC62 antibody provides researchers with a specific reagent for investigating protein translocation, endoplasmic reticulum biology, and disease processes associated with protein trafficking.
Translocation protein SEC62 cooperates with the SEC61 channel and SEC63 cochaperone to mediate insertion of polypeptides into the endoplasmic reticulum lumen. Research using SEC62 antibody has shown that it functions particularly in the import of short signal peptide proteins and stress-inducible proteins. This activity helps maintain proteostasis under conditions of cellular stress, ensuring that unfolded or newly synthesized proteins are efficiently imported and processed.
Studies with SEC62 antibody have revealed that the protein also contributes to the unfolded protein response and endoplasmic reticulum stress adaptation. By regulating the influx of client proteins, Translocation protein SEC62 limits accumulation of misfolded proteins and protects cells from apoptosis. These findings underscore its protective role in maintaining endoplasmic reticulum homeostasis.
In cancer biology, overexpression of SEC62 has been identified in lung, prostate, and thyroid cancers. Research using SEC62 antibody has demonstrated that elevated expression enhances stress tolerance, migration, and invasion, linking the protein to aggressive tumor phenotypes. Because of these properties, SEC62 is being explored as a prognostic biomarker and therapeutic target in oncology.
SEC62 antibody is widely used in western blotting, immunohistochemistry, and immunofluorescence. Western blotting detects SEC62 expression under stress conditions, immunohistochemistry highlights localization to the endoplasmic reticulum in tissues, and immunofluorescence shows its membrane association with endoplasmic reticulum structures. These applications make SEC62 antibody an important reagent in cell biology and disease research.
By supplying validated SEC62 antibody reagents, NSJ Bioreagents supports studies into endoplasmic reticulum function, protein translocation, and cancer. Detection of Translocation protein SEC62 provides insight into how cells regulate protein import under both normal and pathological conditions. -
UniProt
- Q99442
抗原
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