Recombinant TIMM22 抗体
Our Local Distributor
北京 101111
Quick Overview for Recombinant TIMM22 抗体 (ABIN7882539)
抗原
See all TIMM22 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
原理
- TIMM22 Antibody / Translocase of inner mitochondrial membrane 22
-
纯化方法
- Affinity-chromatography
-
免疫原
- A synthesized peptide derived from human TIMM22 was used as the immunogen for the TIMM22 antibody.
-
亚型
- IgG
-
-
anti-Translocase of Inner Mitochondrial Membrane 22 Homolog (TIMM22) (AA 1-194) antibody
TIMM22 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Translocase of Inner Mitochondrial Membrane 22 Homolog (TIMM22) (Internal Region) antibodyTIMM22 适用: 人, 小鼠, 大鼠 WB, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Translocase of Inner Mitochondrial Membrane 22 Homolog (TIMM22) antibodyTIMM22 适用: 小鼠 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Translocase of Inner Mitochondrial Membrane 22 Homolog (TIMM22) antibodyTIMM22 适用: 人 WB, FACS 宿主: 兔 Monoclonal 24GB2355 unconjugated Recombinant Antibody
-
-
应用备注
- Optimal dilution of the TIMM22 antibody should be determined by the researcher.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Store the TIMM22 antibody at -20oC.
-
-
- TIMM22 (Translocase of Inner Mitochondrial Membrane 22 Homolog (TIMM22))
-
别名
- TIMM22
-
背景
-
TIMM22 antibody detects translocase of inner mitochondrial membrane 22, a mitochondrial import protein encoded by the TIMM22 gene. TIMM22 is part of the TIM22 complex, which mediates insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. It recognizes hydrophobic precursor proteins delivered by the small TIM chaperone complex and inserts them into the inner membrane in an energy-dependent process. Through this activity, TIMM22 ensures proper biogenesis of mitochondrial carriers and maintenance of energy metabolism.
TIMM22 antibody is widely applied in mitochondrial biology and protein trafficking research. By detecting TIMM22, scientists can study how mitochondrial import machinery regulates oxidative phosphorylation and cellular energy production. Defects in TIMM22 function lead to impaired assembly of carrier proteins such as ADP/ATP translocases, disrupting mitochondrial function and cellular homeostasis.
Western blot assays detect TIMM22 protein in mitochondrial fractions, while immunohistochemistry highlights expression in tissues with high metabolic demand such as muscle, heart, and brain. Immunofluorescence reveals punctate mitochondrial staining, consistent with its localization in the inner membrane. These methods allow precise analysis of mitochondrial import processes.
Mutations in TIMM22 and disruption of mitochondrial protein import are linked to metabolic disorders, neurodegeneration, and cardiomyopathy. By applying TIMM22 antibody, researchers can investigate how defects in import machinery contribute to disease and explore therapeutic strategies to restore mitochondrial function.
TIMM22 antibody from NSJ Bioreagents provides dependable specificity for studying mitochondrial protein import and energy metabolism. Its strong performance across applications ensures accurate detection of TIMM22 in diverse biological systems. -
UniProt
- Q9Y584
抗原
-
