Recombinant Thyroglobulin 抗体
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Quick Overview for Recombinant Thyroglobulin 抗体 (ABIN7882475)
抗原
See all Thyroglobulin (TG) 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Recombinant Thyroglobulin Antibody
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纯化方法
- Protein G affinity chromatography
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免疫原
- Human thyroid follicular cells were used as the immunogen for the recombinant Thyroglobulin antibody.
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亚型
- IgG2a, kappa
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应用备注
- Optimal dilution of the recombinant Thyroglobulin antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.2 mg/mL
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缓冲液
- 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store the recombinant Thyroglobulin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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- Thyroglobulin (TG)
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别名
- Thyroglobulin
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背景
- MAb rTGB/4744 reacts with a partially defined epitope of human thyroglobulin. This epitope is different form the epitope recognized by mAb < a href=../search_result.php?search_txt=6e1>6E1. Thyroglobulin is a 660 kDa dimeric pre-protein with mutiple glycosylation sites. It is produced by and processed within the thyroid gland to produce the hormone thyroxine and triiodothyronine. Prior to forming dimers, thyroglobulin monomers undergo conformational maturation in the endoplasmic reticulation. The vast majority of follicular carcinomas of the thyroid will give positive immunoreactivity for anti-thyroglobulin even though sometimes only focally. Poorly differentiated carcinomas of the thyroid are frequently anti-thyroglobulin negative. Adenocarcinomas of other-than-thyroid origin do not react with this antibody. This antibody is useful in identification of thyroid carcinoma of the papillary and follicular types. Presence of thyroglobulin in metastatic lesions establishes the thyroid origin of tumor. Anti-thyroglobulin, combined with anti-calcitonin, can identify medullary carcinomas of the thyroid. Furthermore, anti-thyroglobulin, combined with anti-TTF1, can be a reliable marker to differentiate between primary thyroid and lung neoplasms.
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UniProt
- P01266
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途径
- Thyroid Hormone Synthesis
抗原
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