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Recombinant Thyroglobulin 抗体

The 小鼠 单克隆 anti-Thyroglobulin antibody is suitable to detect Thyroglobulin in samples from 人. It has been validated for FACS 和 IHC (p).
产品编号 ABIN7882474
发货至: 中国
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中国
北京 101111
No. 88 KeChuang 6th Street
Beijing Economic Technological Development Area
Room 801-803
4A Biotech Co.,Ltd.
Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for Recombinant Thyroglobulin 抗体 (ABIN7882474)

抗原

See all Thyroglobulin (TG) 抗体
Thyroglobulin (TG)

抗体类型

Recombinant Antibody

适用

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宿主

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小鼠

克隆类型

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单克隆

标记

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This Thyroglobulin antibody is un-conjugated

应用范围

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Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

质量等级

Carrier-free

克隆位点

RTGB-4744
  • 原理

    Recombinant Thyroglobulin Antibody (azide and preservative free)

    纯化方法

    Protein G affinity chromatography

    免疫原

    Human thyroid follicular cells were used as the immunogen for the recombinant Thyroglobulin antibody.

    亚型

    IgG2a, kappa
  • 应用备注

    Optimal dilution of the recombinant Thyroglobulin antibody should be determined by the researcher.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 mg/mL

    缓冲液

    1 mg/mL in 1X PBS, BSA free, sodium azide free

    储存液

    Azide free

    储存条件

    4 °C,-20 °C

    储存方法

    Store the recombinant Thyroglobulin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
  • 抗原

    Thyroglobulin (TG)

    别名

    Thyroglobulin

    背景

    MAb rTGB/4744 reacts with a partially defined epitope of human thyroglobulin. This epitope is different form the epitope recognized by mAb < a href=../search_result.php?search_txt=6e1>6E1. Thyroglobulin is a 660 kDa dimeric pre-protein with mutiple glycosylation sites. It is produced by and processed within the thyroid gland to produce the hormone thyroxine and triiodothyronine. Prior to forming dimers, thyroglobulin monomers undergo conformational maturation in the endoplasmic reticulation. The vast majority of follicular carcinomas of the thyroid will give positive immunoreactivity for anti-thyroglobulin even though sometimes only focally. Poorly differentiated carcinomas of the thyroid are frequently anti-thyroglobulin negative. Adenocarcinomas of other-than-thyroid origin do not react with this antibody. This antibody is useful in identification of thyroid carcinoma of the papillary and follicular types. Presence of thyroglobulin in metastatic lesions establishes the thyroid origin of tumor. Anti-thyroglobulin, combined with anti-calcitonin, can identify medullary carcinomas of the thyroid. Furthermore, anti-thyroglobulin, combined with anti-TTF1, can be a reliable marker to differentiate between primary thyroid and lung neoplasms.

    UniProt

    P01266

    途径

    Thyroid Hormone Synthesis
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