TYMS 抗体
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北京 101111
Quick Overview for TYMS 抗体 (ABIN7882469)
抗原
See all TYMS 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Thymidylate Synthase Antibody
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纯化方法
- Affinity purified
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免疫原
- A synthetic peptide specific to human Thymidylate Synthase / TYMS was used as the immunogen for the Thymidylate Synthase antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the Thymidylate Synthase antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Antibody in PBS with 0.02 % sodium azide, 50 % glycerol and 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the Thymidylate Synthase antibody at -20oC.
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- TYMS (Thymidylate Synthetase (TYMS))
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别名
- Thymidylate Synthase
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背景
- Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1, vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy. [RefSeq]
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UniProt
- P04818
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途径
- Mitotic G1-G1/S Phases
抗原
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