Recombinant SHB 抗体
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北京 101111
Quick Overview for Recombinant SHB 抗体 (ABIN7882356)
抗原
See all SHB 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- SHB Antibody / SH2 domain-containing adapter protein B
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纯化方法
- Affinity-chromatography
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免疫原
- A synthesized peptide derived from human SHB was used as the immunogen for the SHB antibody.
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亚型
- IgG
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anti-Src Homology 2 Domain Containing Adaptor Protein B (SHB) (AA 348-446) antibody
SHB 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4C11 unconjugated
anti-Src Homology 2 Domain Containing Adaptor Protein B (SHB) (AA 250-290) antibodySHB 适用: 人 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB47168 unconjugated
anti-Src Homology 2 Domain Containing Adaptor Protein B (SHB) (C-Term) antibodySHB 适用: 人, 小鼠 WB, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Src Homology 2 Domain Containing Adaptor Protein B (SHB) (N-Term) antibodySHB 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Src Homology 2 Domain Containing Adaptor Protein B (SHB) (C-Term) antibodySHB 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Src Homology 2 Domain Containing Adaptor Protein B (SHB) (N-Term) antibodySHB 适用: 人, 小鼠, 大鼠, Cow, 兔, 犬, 猴, 非洲爪蟾 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Src Homology 2 Domain Containing Adaptor Protein B (SHB) (AA 35-84) antibodySHB 适用: 人, 小鼠, 大鼠, Cow, 兔, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Src Homology 2 Domain Containing Adaptor Protein B (SHB) antibodySHB 适用: 人 WB 宿主: 兔 Monoclonal 24GB2010 unconjugated Recombinant Antibody
anti-Src Homology 2 Domain Containing Adaptor Protein B (SHB) (pTyr246) antibodySHB 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Src Homology 2 Domain Containing Adaptor Protein B (SHB) (pTyr246) antibodySHB 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the SHB antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the SHB antibody at -20oC.
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- SHB (Src Homology 2 Domain Containing Adaptor Protein B (SHB))
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别名
- SHB
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背景
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SHB antibody detects SH2 domain containing adapter protein B, an adaptor protein that participates in signal transduction downstream of receptor and non receptor tyrosine kinases. SHB is involved in transmitting signals that regulate cell proliferation, differentiation, apoptosis, and cytoskeletal rearrangements. Through its SH2 domain, SHB interacts with phosphorylated tyrosine residues on activated receptors and kinases, thereby linking upstream cues to downstream signaling pathways.
SHB antibody is widely used in studies of angiogenesis, immune regulation, and cancer. SHB is known to associate with vascular endothelial growth factor receptor signaling and contributes to endothelial cell migration, survival, and sprouting. In immune cells, SHB modulates T cell receptor signaling and influences activation, proliferation, and cytokine production. Altered expression of SHB has been associated with tumor development and progression, underscoring its importance as both a research target and potential biomarker.
The antibody is suitable for western blotting, immunohistochemistry, immunofluorescence, and flow cytometry. In western blot assays, SHB antibody detects protein bands of expected size, confirming its expression under different cellular conditions. Immunohistochemistry provides tissue distribution patterns, often highlighting expression in vascular structures and immune infiltrates. Immunofluorescence allows colocalization with kinases and receptors, demonstrating its adaptor role within signaling complexes. These applications make SHB antibody a versatile reagent for cell biology and disease research.
SHB has been implicated in diabetes related vascular complications, where it affects insulin signaling and endothelial function. By employing SHB antibody, researchers can explore how adaptor proteins influence metabolic and vascular health. In cancer biology, SHB links growth factor receptor signaling to pathways that drive tumor angiogenesis and invasion. Detecting SHB expression can therefore provide insight into tumor progression and therapy resistance.
NSJ Bioreagents provides SHB antibody as a reliable reagent for studying adaptor mediated signaling. With proven specificity across platforms, this antibody enables detailed investigations into angiogenesis, immunity, and cancer pathways. -
UniProt
- Q15464
抗原
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