Recombinant SNX5 抗体
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北京 101111
Quick Overview for Recombinant SNX5 抗体 (ABIN7882339)
抗原
See all SNX5 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- SNX5 Antibody / Sorting nexin 5
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纯化方法
- Affinity-chromatography
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免疫原
- A synthesized peptide derived from human SNX5 was used as the immunogen for the SNX5 antibody.
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亚型
- IgG
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anti-Sorting Nexin 5 (SNX5) (AA 7-245) antibody
SNX5 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Sorting Nexin 5 (SNX5) antibodyKD Validated SNX5 适用: 人 WB, FACS 宿主: 兔 Monoclonal 24GB2310 unconjugated Recombinant Antibody
anti-Sorting Nexin 5 (SNX5) antibodySNX5 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Sorting Nexin 5 (SNX5) (C-Term) antibodyVerified SNX5 适用: 人 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Sorting Nexin 5 (SNX5) (N-Term) antibodySNX5 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Sorting Nexin 5 (SNX5) (C-Term) antibody (Biotin)Verified SNX5 适用: 人 WB, ELISA, IHC 宿主: 山羊 Polyclonal Biotin
anti-Sorting Nexin 5 (SNX5) (AA 1-50) antibodySNX5 适用: 人, 小鼠 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Sorting Nexin 5 (SNX5) (AA 31-80) antibodySNX5 适用: 人, 小鼠, 大鼠, Cow, 犬, Pig, 马, 兔, 斑马鱼, 豚鼠, 猴, 小鸡 WB 宿主: 兔 Polyclonal unconjugated
anti-Sorting Nexin 5 (SNX5) (AA 145-404) antibodySNX5 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Sorting Nexin 5 (SNX5) (AA 72-121) antibodySNX5 适用: 人, 小鼠, 大鼠, Cow, 犬, Pig, 马, 兔, 斑马鱼, 猴, Bat WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the SNX5 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the SNX5 antibody at -20oC.
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- SNX5 (Sorting Nexin 5 (SNX5))
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别名
- SNX5
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背景
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SNX5 antibody detects sorting nexin 5, a member of the sorting nexin family that regulates endosomal trafficking and membrane remodeling. SNX5 contains a phox homology (PX) domain, which binds phosphoinositides on endosomal membranes, and a BAR domain, which promotes membrane curvature and tubulation. Together, these domains allow SNX5 to coordinate cargo retrieval from endosomes and direct proteins to specific intracellular destinations.
Research using SNX5 antibody has shown that SNX5 participates in the retromer complex, where it cooperates with other sorting nexins such as SNX1 and SNX2 to mediate retrograde transport of receptors and enzymes. Disruption of SNX5 function impairs recycling of critical cargo such as cation-independent mannose-6-phosphate receptors, affecting lysosomal enzyme trafficking. These defects can contribute to lysosomal storage disorders and cellular stress responses.
SNX5 has also been linked to viral infection and cancer biology. Certain viruses exploit SNX5-mediated endosomal pathways to promote entry and replication, while altered expression of SNX5 in cancer may influence cell signaling, proliferation, and migration. Its role in trafficking growth factor receptors underscores its significance in tumor biology. In immune cells, SNX5 contributes to antigen presentation by regulating transport of major histocompatibility complex molecules.
Antibodies against SNX5 are validated for western blot, immunohistochemistry, and immunofluorescence. These tools enable analysis of protein expression, intracellular localization, and retromer function. Clone-based antibodies ensure specificity, distinguishing SNX5 from other sorting nexins with overlapping roles.
NSJ Bioreagents provides this SNX5 antibody to support studies in endosomal trafficking, retromer biology, and disease pathways. -
UniProt
- Q9Y5X3
抗原
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