Recombinant Sorting Nexin 4 抗体
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Quick Overview for Recombinant Sorting Nexin 4 抗体 (ABIN7882338)
抗原
See all Sorting Nexin 4 (SNX4) 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- SNX4 Antibody / Sorting nexin 4
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纯化方法
- Affinity-chromatography
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免疫原
- A synthesized peptide derived from human SNX4 was used as the immunogen for the SNX4 antibody.
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亚型
- IgG
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anti-Sorting Nexin 4 (SNX4) (AA 1-450) antibody
SNX4 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Sorting Nexin 4 (SNX4) (AA 1-450) antibodySNX4 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Sorting Nexin 4 (SNX4) (AA 341-450) antibodySNX4 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4H8 unconjugated
anti-Sorting Nexin 4 (SNX4) antibodyKD Validated SNX4 适用: 人 WB, FACS 宿主: 兔 Monoclonal 24GB2335 unconjugated Recombinant Antibody
anti-Sorting Nexin 4 (SNX4) (AA 1-450) antibodySNX4 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Sorting Nexin 4 (SNX4) (Internal Region) antibodySNX4 适用: 人, 小鼠, 大鼠 WB, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Sorting Nexin 4 (SNX4) (AA 391-420), (C-Term) antibodySNX4 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB32616 unconjugated
anti-Sorting Nexin 4 (SNX4) (AA 362-411) antibodySNX4 适用: 人, 小鼠, 大鼠, 猴, 马, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Sorting Nexin 4 (SNX4) (AA 398-428), (C-Term) antibodySNX4 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the SNX4 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store the SNX4 antibody at -20oC.
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- Sorting Nexin 4 (SNX4)
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别名
- SNX4
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背景
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SNX4 antibody detects sorting nexin 4, a member of the sorting nexin family encoded by the SNX4 gene. Sorting nexins are characterized by the presence of a phox homology domain that binds phosphoinositides, enabling association with endosomal membranes. SNX4 is primarily involved in endosomal trafficking, cargo sorting, and membrane remodeling. By directing proteins to recycling or degradative pathways, SNX4 maintains cellular homeostasis and regulates receptor signaling.
SNX4 antibody is widely applied in studies of membrane trafficking, endocytosis, and signal transduction. Sorting nexin 4 is part of the retromer independent recycling pathway and contributes to the trafficking of proteins such as the transferrin receptor. Disruption of SNX4 function impairs endosomal sorting and alters nutrient uptake, receptor turnover, and intracellular signaling dynamics. By detecting SNX4, researchers can explore how sorting nexins control endosomal recycling and cell surface composition.
In western blot assays, SNX4 antibody detects protein bands of the expected size in cell and tissue extracts. Immunohistochemistry highlights expression in epithelial and neuronal tissues, while immunofluorescence maps SNX4 distribution on endosomal membranes. These methods support detailed analysis of endosomal dynamics.
SNX4 has been implicated in neurodegenerative disease and cancer. Altered expression affects autophagy, mitochondrial function, and neuronal survival. In oncology, abnormal SNX4 activity influences growth factor receptor trafficking and signaling, potentially affecting tumor progression. By applying SNX4 antibody, scientists can investigate how sorting nexin mediated trafficking pathways contribute to both normal physiology and disease.
SNX4 antibody from NSJ Bioreagents provides dependable specificity for exploring membrane trafficking and signaling. Its versatility across assays makes it an essential reagent for cell biology and disease related research. -
UniProt
- O95219
抗原
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