SLC9A3 抗体
Our Local Distributor
北京 101111
Quick Overview for SLC9A3 抗体 (ABIN7882330)
抗原
See all SLC9A3 抗体适用
宿主
克隆类型
标记
应用范围
-
-
原理
- SLC9A3 Antibody / Sodium/hydrogen exchanger 3
-
纯化方法
- Immunogen affinity purified
-
免疫原
- E.coli-derived human SLC9A3 recombinant protein (Position: 667-831) was used as the immunogen for the SLC9A3 antibody.
-
亚型
- IgG
-
-
anti-Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 3 (SLC9A3) antibody
SLC9A3 适用: 大鼠 WB, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 3 (SLC9A3) antibodySLC9A3 适用: 大鼠, 小鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 3 (SLC9A3) antibody (Atto 390)SLC9A3 适用: 大鼠 WB, IHC, ICC, IF 宿主: 兔 Polyclonal Atto 390
anti-Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 3 (SLC9A3) antibody (Atto 488)SLC9A3 适用: 大鼠 WB, IHC, ICC, IF 宿主: 兔 Polyclonal Atto 488
anti-Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 3 (SLC9A3) antibody (Atto 594)SLC9A3 适用: 大鼠 WB, IHC, ICC, IF 宿主: 兔 Polyclonal Atto 594
anti-Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 3 (SLC9A3) antibody (Biotin)SLC9A3 适用: 大鼠 WB, IHC, ICC, IF 宿主: 兔 Polyclonal Biotin
anti-Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 3 (SLC9A3) antibody (FITC)SLC9A3 适用: 大鼠 WB, IHC, ICC, IF 宿主: 兔 Polyclonal FITC
anti-Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 3 (SLC9A3) antibody (PerCP)SLC9A3 适用: 大鼠 WB, IHC, ICC, IF 宿主: 兔 Polyclonal PerCP
anti-Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 3 (SLC9A3) antibody (HRP)SLC9A3 适用: 大鼠 WB, IHC, ICC, IF 宿主: 兔 Polyclonal HRP
anti-Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 3 (SLC9A3) antibody (APC)SLC9A3 适用: 大鼠 WB, IHC, ICC, IF 宿主: 兔 Polyclonal APC
-
-
应用备注
- Optimal dilution of the SLC9A3 antibody should be determined by the researcher.
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
-
缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
-
储存条件
- 4 °C,-20 °C
-
储存方法
- After reconstitution, the SLC9A3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
-
-
- SLC9A3 (Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 3 (SLC9A3))
-
别名
- SLC9A3
-
背景
-
SLC9A3 antibody detects Sodium/hydrogen exchanger 3, a membrane transporter that regulates intracellular pH and sodium absorption in epithelial tissues. SLC9A3 plays a vital role in electrolyte balance, acid-base homeostasis, and fluid reabsorption in the kidney and intestine. The SLC9A3 antibody is widely used in renal physiology, gastrointestinal, and cell signaling research to study ion transport mechanisms and epithelial function.
SLC9A3 is encoded by the SLC9A3 gene located on human chromosome 5p15.33. The protein is approximately 834 amino acids long and belongs to the solute carrier 9 family of sodium/hydrogen exchangers (NHEs). It is predominantly expressed in the apical membrane of renal proximal tubule and intestinal epithelial cells, where it exchanges intracellular hydrogen ions for extracellular sodium ions, helping to regulate pH and volume.
The SLC9A3 antibody detects a 90 kilodalton band by western blot and shows apical membrane staining in epithelial tissues under immunofluorescence microscopy. Through its role in sodium absorption, SLC9A3 contributes to systemic blood pressure control and fluid balance. Regulation of SLC9A3 activity is mediated by phosphorylation and interaction with scaffold proteins such as NHERF1 and ezrin, linking it to hormonal control by angiotensin II and parathyroid hormone.
Mutations in SLC9A3 cause congenital secretory diarrhea and male infertility due to defective sodium transport and fluid absorption. In the kidney, SLC9A3 dysfunction results in impaired bicarbonate reabsorption and metabolic acidosis. Its regulation is critical for maintaining acid-base equilibrium, and its altered expression has been linked to cystic fibrosis and inflammatory bowel disease.
As an essential component of epithelial ion transport, SLC9A3 integrates metabolic, hormonal, and mechanical stimuli to maintain homeostasis. NSJ Bioreagents provides a validated SLC9A3 antibody optimized for its applications, supporting research into renal physiology, intestinal absorption, and electrolyte balance. -
UniProt
- P48764
-
途径
- Proton Transport
抗原
-
