Recombinant SEC24D 抗体
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北京 101111
Quick Overview for Recombinant SEC24D 抗体 (ABIN7882216)
抗原
See all SEC24D 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- SEC24D Antibody
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纯化方法
- Affinity-chromatography
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免疫原
- A synthesized peptide derived from human SEC24D was used as the immunogen for the SEC24D antibody.
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亚型
- IgG
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anti-SEC24 Family, Member D (S. Cerevisiae) (SEC24D) (AA 935-1032) antibody
SEC24D 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1A8 unconjugated
anti-SEC24 Family, Member D (S. Cerevisiae) (SEC24D) antibodyKD Validated SEC24D 适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB2510 unconjugated Recombinant Antibody
anti-SEC24 Family, Member D (S. Cerevisiae) (SEC24D) (AA 935-1032) antibodySEC24D 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-SEC24 Family, Member D (S. Cerevisiae) (SEC24D) (AA 830-1000) antibodySEC24D 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-SEC24 Family, Member D (S. Cerevisiae) (SEC24D) (AA 235-266) antibodySEC24D 适用: 人 WB 宿主: 兔 Polyclonal RB55324 unconjugated
anti-SEC24 Family, Member D (S. Cerevisiae) (SEC24D) (AA 1-50) antibodySEC24D 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-SEC24 Family, Member D (S. Cerevisiae) (SEC24D) antibodyKD Validated SEC24D 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Monoclonal unconjugated Recombinant Antibody
anti-SEC24 Family, Member D (S. Cerevisiae) (SEC24D) antibodySEC24D 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Monoclonal 30S42 unconjugated
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应用备注
- Optimal dilution of the SEC24D antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the SEC24D antibody at -20oC.
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- SEC24D (SEC24 Family, Member D (S. Cerevisiae) (SEC24D))
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别名
- SEC24D
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背景
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SEC24D antibody detects protein transport protein Sec24D, a component of the coat protein complex II (COPII) vesicle trafficking system. SEC24D functions as a cargo-binding adaptor, selecting proteins for export from the endoplasmic reticulum to the Golgi apparatus. As one of four paralogs in the SEC24 family, SEC24D provides substrate specificity, ensuring correct sorting of a wide range of secretory and membrane proteins. Proper activity of SEC24D is fundamental to protein trafficking and overall cellular homeostasis.
Research using SEC24D antibody has demonstrated the protein's involvement in human disease. Mutations in SEC24D cause autosomal recessive skeletal disorders such as osteogenesis imperfecta and Cole-Carpenter syndrome, where impaired secretion of collagen and other matrix proteins disrupts bone development. SEC24D dysfunction can also affect immune signaling and neural development, reflecting its role in multiple cargo export pathways.
In cancer biology, SEC24D has been implicated in tumor progression due to its regulation of protein secretion and cell signaling. Tumor cells often exploit secretory pathways to remodel their microenvironment, and altered expression of SEC24D may enhance invasive behavior. In addition, SEC24D participates in the trafficking of receptors and adhesion molecules, making it relevant for studies on metastasis and cellular communication.
Antibodies against SEC24D are validated for western blot, immunohistochemistry, and immunofluorescence. These reagents enable detection of SEC24D across tissues and allow analysis of subcellular localization within ER exit sites. Clone-based antibodies ensure specificity, distinguishing SEC24D from related SEC24 family members. Such tools are valuable for researchers studying protein trafficking, secretion, and disease mechanisms tied to the secretory pathway.
NSJ Bioreagents offers this SEC24D antibody to support studies in cell biology, developmental disorders, and cancer research. -
UniProt
- O94855
抗原
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