Recombinant SAFB 抗体
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北京 101111
Quick Overview for Recombinant SAFB 抗体 (ABIN7882213)
抗原
See all SAFB 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- SAFB Antibody / Scaffold attachment factor B
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纯化方法
- Affinity-chromatography
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免疫原
- A synthesized peptide derived from human SAFB was used as the immunogen for the SAFB antibody.
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亚型
- IgG
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anti-Scaffold Attachment Factor B (SAFB) antibody
SAFB 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Scaffold Attachment Factor B (SAFB) (AA 1-200) antibodySAFB 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Scaffold Attachment Factor B (SAFB) antibodySAFB 适用: 人 WB, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Scaffold Attachment Factor B (SAFB) (AA 111-200) antibodySAFB 适用: 人 WB, IF, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 5A11 unconjugated
anti-Scaffold Attachment Factor B (SAFB) (AA 111-201) antibodySAFB 适用: 人 WB, IHC, IF, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 5A11 unconjugated
anti-Scaffold Attachment Factor B (SAFB) antibodyKD Validated SAFB 适用: 人 WB, FACS 宿主: 兔 Monoclonal 25GB3320 unconjugated Recombinant Antibody
anti-Scaffold Attachment Factor B (SAFB) (C-Term) antibodySAFB 适用: 人, 小鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Scaffold Attachment Factor B (SAFB) (AA 775-825) antibodySAFB 适用: 人 WB, IP, IHC (fp) 宿主: 兔 Polyclonal unconjugated
anti-Scaffold Attachment Factor B (SAFB) (C-Term) antibodySAFB 适用: 人, 小鼠 WB, IP, IHC (fp) 宿主: 兔 Polyclonal unconjugated
anti-Scaffold Attachment Factor B (SAFB) (C-Term) antibodySAFB 适用: 人, 小鼠, 兔 IHC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the SAFB antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the SAFB antibody at -20oC.
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- SAFB (Scaffold Attachment Factor B (SAFB))
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别名
- SAFB
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背景
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SAFB antibody detects scaffold attachment factor B, a multifunctional nuclear protein encoded by the SAFB gene. SAFB belongs to a family of proteins that bind scaffold/matrix attachment regions of DNA, thereby influencing chromatin structure and transcriptional regulation. It contains RNA recognition motifs and domains for protein-protein interactions, linking it to RNA processing, transcriptional repression, and nuclear architecture.
SAFB antibody is widely applied in molecular biology, transcriptional regulation, and cancer research. SAFB associates with nuclear matrix elements and modulates expression of hormone responsive genes. It also functions as a corepressor of estrogen receptor alpha, impacting signaling pathways critical in breast cancer biology. By detecting SAFB, researchers can explore mechanisms of gene regulation at the interface of DNA, RNA, and protein interactions.
Western blot assays detect SAFB protein in nuclear extracts, while immunohistochemistry maps expression in hormone responsive tissues and tumors. Immunofluorescence highlights nuclear speckle localization, consistent with its role in transcriptional complexes. These applications enable detailed characterization of SAFB across tissues and conditions.
SAFB also contributes to stress response pathways. It regulates heat shock protein gene expression and participates in apoptosis and cell cycle control. Mutations or altered expression of SAFB have been linked to breast cancer, prostate cancer, and neurological disorders. By applying SAFB antibody, scientists can evaluate its diverse functions in gene regulation, hormone signaling, and disease pathogenesis.
SAFB antibody from NSJ Bioreagents provides reliable specificity for analyzing nuclear scaffold interactions and transcriptional repression. Its performance across multiple assays ensures accurate results in both research and diagnostic contexts. -
UniProt
- Q15424
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途径
- Intracellular Steroid Hormone Receptor Signaling Pathway
抗原
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