RUVBL1 抗体
Our Local Distributor
北京 101111
Quick Overview for RUVBL1 抗体 (ABIN7882186)
抗原
See all RUVBL1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
原理
- RuvB-like 1 Antibody / RUVBL1 / TIP49A
-
纯化方法
- Antigen affinity purified
-
免疫原
- Recombinant human protein was used as the immunogen for the RuvB-like 1 antibody.
-
亚型
- Ig Fraction
-
-
anti-RuvB-Like 1 (E. Coli) (RUVBL1) (AA 1-240) antibody
RUVBL1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-RuvB-Like 1 (E. Coli) (RUVBL1) (AA 1-456) antibodyRUVBL1 适用: 人 WB, ELISA, IF, PLA 宿主: 小鼠 Monoclonal 3G4-1F8 unconjugated
anti-RuvB-Like 1 (E. Coli) (RUVBL1) (AA 13-23) antibodyRUVBL1 适用: 人, 小鼠, 大鼠, 猴 WB, IHC, ELISA, FACS, IF, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-RuvB-Like 1 (E. Coli) (RUVBL1) (AA 101-400) antibodyRUVBL1 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-RuvB-Like 1 (E. Coli) (RUVBL1) antibodyRUVBL1 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB23096 unconjugated
anti-RuvB-Like 1 (E. Coli) (RUVBL1) antibodyRUVBL1 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-RuvB-Like 1 (E. Coli) (RUVBL1) antibodyRUVBL1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-RuvB-Like 1 (E. Coli) (RUVBL1) antibodyKD Validated RUVBL1 适用: 人 WB, FACS 宿主: 兔 Monoclonal 25GB2630 unconjugated Recombinant Antibody
anti-RuvB-Like 1 (E. Coli) (RUVBL1) antibodyRUVBL1 适用: 人 WB, FACS, ICC, DB 宿主: 小鼠 Monoclonal 2943C1a unconjugated
anti-RuvB-Like 1 (E. Coli) (RUVBL1) (AA 247-280) antibodyRUVBL1 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB8415 unconjugated
-
-
应用备注
- The stated application concentrations are suggested starting points. Titration of the RuvB-like 1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Aliquot the RuvB-like 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
-
-
- RUVBL1 (RuvB-Like 1 (E. Coli) (RUVBL1))
-
别名
- RuvB-like 1
-
背景
- RUVBL1 possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity. It is a component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. RUVBL1 plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1 -CTNNB1 complex. High levels of autoantibodies against RUVBL1 are detected in sera of patients with autoimmune diseases such as polymyositis/dermatomyosistis and autoimmune hepatitis.
-
UniProt
- Q9Y265
-
途径
- Telomere Maintenance
抗原
-
