Recombinant RPN1 抗体
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北京 101111
Quick Overview for Recombinant RPN1 抗体 (ABIN7882169)
抗原
See all RPN1 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- RPN1 Antibody / Ribophorin I
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纯化方法
- Affinity chromatography
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免疫原
- A synthesized peptide derived from human Ribophorin I was used as the immunogen for the RPN1 antibody.
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亚型
- IgG
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anti-Ribophorin 1 (RPN1) antibody
RPN1 适用: 人, 犬 WB, IHC, FACS, IF, IHC (p) 宿主: 小鼠 Monoclonal 6A9 unconjugated
anti-Ribophorin 1 (RPN1) antibodyRPN1 适用: 人, 大鼠, 猴 WB, IHC, FACS, IF, IHC (p) 宿主: 小鼠 Monoclonal 3E1 unconjugated
anti-Ribophorin 1 (RPN1) antibodyRPN1 适用: 人, 犬, 猴 WB, IHC, FACS, IHC (p) 宿主: 小鼠 Monoclonal 3H3 unconjugated
anti-Ribophorin 1 (RPN1) (AA 20-280) antibodyRPN1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ribophorin 1 (RPN1) (AA 20-280) antibodyRPN1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Ribophorin 1 (RPN1) antibodyKD Validated RPN1 适用: 人 WB, ICC, FACS 宿主: 兔 Monoclonal 24GB1090 unconjugated Recombinant Antibody
anti-Ribophorin 1 (RPN1) (AA 196-495) antibodyRPN1 适用: 人 WB, IHC, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
anti-Ribophorin 1 (RPN1) (Middle Region) antibodyRPN1 适用: 人, 小鼠, 大鼠, 犬, Cow, 马, 兔, 豚鼠, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
anti-Ribophorin 1 (RPN1) antibodyRPN1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Ribophorin 1 (RPN1) (C-Term) antibodyRPN1 适用: 人 WB, IP, ICC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the RPN1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the RPN1 antibody at -20oC.
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- RPN1 (Ribophorin 1 (RPN1))
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别名
- RPN1
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背景
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RPN1 antibody detects Ribophorin I, encoded by the RPN1 gene. Ribophorin I is an integral membrane glycoprotein of the rough endoplasmic reticulum and a component of the oligosaccharyltransferase complex. This complex mediates the transfer of core oligosaccharides to nascent polypeptides, a key step in protein N linked glycosylation. RPN1 antibody provides researchers with an important reagent to study protein maturation, endoplasmic reticulum function, and secretory pathway biology.
Protein glycosylation is a critical post translational modification that ensures proper folding, stability, and function of many secreted and membrane proteins. Research using RPN1 antibody has shown that Ribophorin I contributes to substrate recognition and complex stability within the oligosaccharyltransferase machinery. By supporting efficient glycosylation, RPN1 plays a vital role in quality control and trafficking of glycoproteins through the secretory pathway.
Studies with RPN1 antibody have revealed that disruption of Ribophorin I function impairs N linked glycosylation, leading to misfolded proteins and activation of endoplasmic reticulum stress responses. Persistent dysfunction contributes to protein misfolding diseases and disorders of glycoprotein biosynthesis. This makes RPN1 a critical factor in maintaining protein homeostasis.
In cancer biology, RPN1 expression has been linked to tumor progression and therapeutic resistance. Research using RPN1 antibody has demonstrated that overexpression of Ribophorin I supports increased protein synthesis and folding capacity in tumor cells, enabling rapid proliferation and adaptation to stress. Elevated levels of RPN1 have been associated with poor prognosis in certain cancers, positioning it as a potential biomarker.
RPN1 antibody is widely used in western blotting, immunohistochemistry, and immunofluorescence. Western blotting confirms protein expression and size, immunohistochemistry localizes RPN1 in rough endoplasmic reticulum rich tissues, and immunofluorescence reveals perinuclear reticular distribution. These applications make RPN1 antibody indispensable in research on protein folding and secretion.
By providing validated RPN1 antibody reagents, NSJ Bioreagents supports studies into glycosylation, endoplasmic reticulum biology, and cancer research. Detection of Ribophorin I allows researchers to investigate how secretory pathway components regulate protein maturation and disease. -
UniProt
- P04843
抗原
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