Recombinant RAB22A 抗体
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北京 101111
Quick Overview for Recombinant RAB22A 抗体 (ABIN7882122)
抗原
See all RAB22A 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- RAB22A Antibody / Ras related protein Rab-22A
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纯化方法
- Affinity-chromatography
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免疫原
- A synthesized peptide derived from human RAB22A was used as the immunogen for the RAB22A antibody.
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亚型
- IgG
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anti-RAB22A, Member RAS Oncogene Family (RAB22A) antibody
RAB22A 适用: 人 WB, ICC, FACS 宿主: 兔 Monoclonal 24GB1000 unconjugated Recombinant Antibody
anti-RAB22A, Member RAS Oncogene Family (RAB22A) (Middle Region) antibodyRAB22A 适用: 人, 小鼠, 大鼠, 犬, Cow, 马, Pig, 兔, 斑马鱼, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-RAB22A, Member RAS Oncogene Family (RAB22A) (AA 1-194) antibodyRAB22A 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2B12 unconjugated
anti-RAB22A, Member RAS Oncogene Family (RAB22A) (C-Term) antibodyRAB22A 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-RAB22A, Member RAS Oncogene Family (RAB22A) antibodyRAB22A 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-RAB22A, Member RAS Oncogene Family (RAB22A) (AA 1-194) antibodyRAB22A 适用: 人 IP 宿主: 兔 Polyclonal unconjugated
anti-RAB22A, Member RAS Oncogene Family (RAB22A) (AA 1-194) antibodyRAB22A 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-RAB22A, Member RAS Oncogene Family (RAB22A) (C-Term) antibodyRAB22A 适用: 人, 小鼠, 大鼠, 犬, Cow, 马, Pig, 兔, 斑马鱼, 猴, Bat, 小鸡 WB 宿主: 兔 Polyclonal unconjugated
anti-RAB22A, Member RAS Oncogene Family (RAB22A) antibodyRAB22A 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-RAB22A, Member RAS Oncogene Family (RAB22A) (AA 166-192), (C-Term) antibodyRAB22A 适用: 人 WB 宿主: 兔 Polyclonal RB39644 unconjugated
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应用备注
- Optimal dilution of the RAB22A antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the RAB22A antibody at -20oC.
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- RAB22A (RAB22A, Member RAS Oncogene Family (RAB22A))
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别名
- RAB22A
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背景
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RAB22A antibody detects Ras related protein Rab-22A, a member of the Rab family of small GTPases encoded by the RAB22A gene. Rab proteins are key regulators of vesicle trafficking, controlling vesicle formation, motility, tethering, and fusion. RAB22A localizes to early endosomes and recycling endosomes, where it regulates cargo sorting and endosomal membrane dynamics. By cycling between an active GTP bound state and an inactive GDP bound state, RAB22A coordinates membrane trafficking and receptor recycling.
RAB22A antibody is widely applied in studies of endocytosis, membrane trafficking, and receptor regulation. RAB22A interacts with Rabex-5 and Rabaptin-5 to control early endosome maturation and crosstalk with Rab5 mediated pathways. It also contributes to recycling of transferrin receptors and growth factor receptors to the plasma membrane. By detecting RAB22A, researchers can examine how membrane trafficking proteins influence nutrient uptake, receptor signaling, and cellular homeostasis.
Western blot assays identify RAB22A protein bands of expected size in cell and tissue lysates. Immunohistochemistry highlights expression in epithelial and neuronal tissues, while immunofluorescence reveals punctate distribution consistent with endosomal localization. These techniques make RAB22A antibody versatile for cell biology research.
Dysregulation of RAB22A has been linked to cancer and neurodegeneration. Elevated RAB22A expression enhances receptor recycling and signaling, promoting tumor cell survival, invasion, and therapy resistance. In neurons, altered RAB22A activity contributes to trafficking defects and synaptic dysfunction. By applying RAB22A antibody, scientists can explore how small GTPases regulate intracellular trafficking and disease mechanisms.
Beyond cancer and neuroscience, RAB22A also participates in immune signaling and pathogen entry. Certain viruses exploit RAB22A regulated endocytosis for infection, highlighting its role in host-pathogen interactions. Its broad biological functions emphasize the importance of RAB22A antibody in both basic and translational research.
RAB22A antibody from NSJ Bioreagents delivers reliable specificity for studying Rab GTPase biology, vesicle trafficking, and signaling. Its strong performance across assays ensures accurate detection in diverse contexts. -
UniProt
- Q9UL26
抗原
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