Recombinant PPM1G 抗体
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Quick Overview for Recombinant PPM1G 抗体 (ABIN7882087)
抗原
See all PPM1G 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- PPM1G Antibody / Protein phosphatase Mg2+/Mn2+ dependent 1G
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纯化方法
- Affinity-chromatography
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免疫原
- A synthesized peptide derived from human PPM1G was used as the immunogen for the PPM1G antibody.
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亚型
- IgG
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anti-Protein Phosphatase, Mg2+/Mn2+ Dependent, 1G (PPM1G) antibody
KD Validated PPM1G 适用: 人 WB, FACS, IF (p) 宿主: 兔 Monoclonal 23GB2585 unconjugated Recombinant Antibody
anti-Protein Phosphatase, Mg2+/Mn2+ Dependent, 1G (PPM1G) antibodyPPM1G 适用: 人, 犬 WB, IF 宿主: 小鼠 Monoclonal 1C12 unconjugated
anti-Protein Phosphatase, Mg2+/Mn2+ Dependent, 1G (PPM1G) antibodyKD Validated PPM1G 适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB2590 unconjugated Recombinant Antibody
anti-Protein Phosphatase, Mg2+/Mn2+ Dependent, 1G (PPM1G) (AA 317-546) antibodyPPM1G 适用: 人 WB, IHC, ELISA, IF, ICC 宿主: 小鼠 Monoclonal k1G6 unconjugated
anti-Protein Phosphatase, Mg2+/Mn2+ Dependent, 1G (PPM1G) antibodyPPM1G 适用: 人, 小鼠, 大鼠 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase, Mg2+/Mn2+ Dependent, 1G (PPM1G) (AA 317-546) antibodyPPM1G 适用: 人 WB, IHC, ELISA 宿主: 小鼠 Monoclonal k1G6 unconjugated
anti-Protein Phosphatase, Mg2+/Mn2+ Dependent, 1G (PPM1G) (AA 400-450) antibodyPPM1G 适用: 人, 小鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase, Mg2+/Mn2+ Dependent, 1G (PPM1G) (AA 462-544) antibodyPPM1G 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Protein Phosphatase, Mg2+/Mn2+ Dependent, 1G (PPM1G) antibodyPPM1G 适用: 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase, Mg2+/Mn2+ Dependent, 1G (PPM1G) antibodyPPM1G 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
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应用备注
- Optimal dilution of the PPM1G antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the PPM1G antibody at -20oC.
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- PPM1G (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1G (PPM1G))
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别名
- PPM1G
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背景
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PPM1G antibody detects protein phosphatase, Mg2+/Mn2+ dependent 1G, a member of the PP2C family of serine/threonine phosphatases. PPM1G is a nuclear-localized enzyme that regulates pre-mRNA splicing, chromatin remodeling, and DNA damage responses. By dephosphorylating specific substrates, PPM1G ensures proper assembly of the spliceosome and contributes to transcriptional control.
Research using PPM1G antibody has demonstrated the enzyme's significance in cell cycle regulation and genome stability. PPM1G participates in the DNA damage response by dephosphorylating gamma-H2AX, a key histone mark of double-strand breaks. This activity supports checkpoint recovery and restoration of normal transcription after DNA repair. In addition, PPM1G regulates the phosphorylation status of spliceosomal proteins, influencing alternative splicing decisions critical for development and stress adaptation.
PPM1G has been studied in cancer, where its overexpression promotes survival of tumor cells by modulating DNA repair and splicing pathways. Aberrant activity may enable oncogenic transcript variants or resistance to DNA-damaging therapies. Conversely, reduced PPM1G function can impair cell survival under stress, underscoring its context-dependent roles in disease. In neurobiology, altered expression of PPM1G has been linked to synaptic signaling and cognitive function, connecting phosphatase activity to brain health.
Antibodies against PPM1G are validated for western blot, immunohistochemistry, immunofluorescence, and immunoprecipitation. These reagents allow researchers to monitor nuclear localization, assess changes in expression, and study interactions with chromatin-associated proteins. Clone-based antibodies provide the specificity needed to distinguish PPM1G from other PP2C family members.
NSJ Bioreagents supplies this PPM1G antibody to support studies in splicing regulation, DNA repair, and cancer biology. -
UniProt
- O15355
抗原
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