Recombinant PPM1G 抗体
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Quick Overview for Recombinant PPM1G 抗体 (ABIN7882086)
抗原
See all PPM1G 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- PPM1G Antibody / Protein phosphatase 1G
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纯化方法
- Affinity chromatography
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免疫原
- A synthesized peptide derived from human PPM1G was used as the immunogen for the PPM1G antibody.
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亚型
- IgG
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anti-Protein Phosphatase, Mg2+/Mn2+ Dependent, 1G (PPM1G) antibody
KD Validated PPM1G 适用: 人 WB, FACS, IF (p) 宿主: 兔 Monoclonal 23GB2585 unconjugated Recombinant Antibody
anti-Protein Phosphatase, Mg2+/Mn2+ Dependent, 1G (PPM1G) antibodyPPM1G 适用: 人, 犬 WB, IF 宿主: 小鼠 Monoclonal 1C12 unconjugated
anti-Protein Phosphatase, Mg2+/Mn2+ Dependent, 1G (PPM1G) antibodyKD Validated PPM1G 适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB2590 unconjugated Recombinant Antibody
anti-Protein Phosphatase, Mg2+/Mn2+ Dependent, 1G (PPM1G) (AA 317-546) antibodyPPM1G 适用: 人 WB, IHC, ELISA, IF, ICC 宿主: 小鼠 Monoclonal k1G6 unconjugated
anti-Protein Phosphatase, Mg2+/Mn2+ Dependent, 1G (PPM1G) antibodyPPM1G 适用: 人, 小鼠, 大鼠 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase, Mg2+/Mn2+ Dependent, 1G (PPM1G) (AA 317-546) antibodyPPM1G 适用: 人 WB, IHC, ELISA 宿主: 小鼠 Monoclonal k1G6 unconjugated
anti-Protein Phosphatase, Mg2+/Mn2+ Dependent, 1G (PPM1G) (AA 400-450) antibodyPPM1G 适用: 人, 小鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase, Mg2+/Mn2+ Dependent, 1G (PPM1G) (AA 462-544) antibodyPPM1G 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Protein Phosphatase, Mg2+/Mn2+ Dependent, 1G (PPM1G) antibodyPPM1G 适用: 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase, Mg2+/Mn2+ Dependent, 1G (PPM1G) antibodyPPM1G 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
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应用备注
- Optimal dilution of the PPM1G antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the PPM1G antibody at -20oC.
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- PPM1G (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1G (PPM1G))
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别名
- PPM1G
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背景
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PPM1G antibody detects Protein phosphatase 1G, encoded by the PPM1G gene. Protein phosphatase 1G belongs to the PP2C family of serine threonine phosphatases, which are magnesium or manganese dependent enzymes involved in negative regulation of cell signaling. PPM1G dephosphorylates specific substrates to modulate cell cycle progression, DNA damage repair, pre mRNA splicing, and chromatin remodeling. PPM1G antibody is a versatile reagent for exploring how phosphatase activity contributes to cellular regulation and disease.
Protein phosphatase 1G has been implicated in regulation of the G2/M transition of the cell cycle. Research using PPM1G antibody has shown that depletion of this phosphatase delays mitotic entry and leads to accumulation of phosphorylated cyclin dependent kinase substrates. By reversing phosphorylation of key regulators, PPM1G ensures proper timing of mitotic onset. Its involvement in cell cycle checkpoints makes it critical for maintaining genomic stability and preventing uncontrolled proliferation.
PPM1G also plays a role in DNA damage responses. Studies using PPM1G antibody have demonstrated that it dephosphorylates histone H2AX and other chromatin associated substrates, facilitating repair and chromatin restoration following DNA double strand breaks. This highlights its function as a chromatin associated phosphatase linking signaling pathways to epigenetic control. Dysregulation of PPM1G expression or activity may impair DNA repair, contributing to mutagenesis and cancer susceptibility.
In addition to DNA repair and cell cycle regulation, PPM1G is involved in pre mRNA splicing. By dephosphorylating components of the spliceosome, it regulates splicing factor dynamics and mRNA maturation. Research with PPM1G antibody has revealed that it controls alternative splicing patterns and transcriptional responses, linking phosphatase activity to gene expression. This broadens its functional impact beyond canonical phosphatase roles and highlights its integration into multiple layers of gene regulation.
PPM1G antibody is widely applied in western blotting, immunohistochemistry, and immunoprecipitation. Western blotting demonstrates expression across proliferative tissues, while immunohistochemistry localizes the phosphatase in nuclei of dividing cells. Immunoprecipitation with PPM1G antibody isolates its complexes, enabling characterization of substrates and interaction partners. Together, these approaches make PPM1G antibody an important tool for studying signaling, genome maintenance, and transcriptional regulation.
By supplying validated PPM1G antibody reagents, NSJ Bioreagents supports research into phosphatase biology, DNA repair, and cell cycle regulation. Detection of Protein phosphatase 1G enhances our understanding of how dephosphorylation contributes to cellular control and disease mechanisms. -
UniProt
- O15355
抗原
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