Recombinant PDIA4 抗体
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北京 101111
Quick Overview for Recombinant PDIA4 抗体 (ABIN7882074)
抗原
See all PDIA4 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- PDIA4 Antibody / Protein disulfide-isomerase A4 / ERp72
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纯化方法
- Affinity chromatography
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免疫原
- A synthesized peptide derived from human ERp72 was used as the immunogen for the PDIA4 antibody.
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亚型
- IgG
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anti-Protein Disulfide Isomerase Family A, Member 4 (PDIA4) (AA 505-636) antibody
PDIA4 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Protein Disulfide Isomerase Family A, Member 4 (PDIA4) antibodyPDIA4 适用: 人, 小鼠 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 2A11 unconjugated
anti-Protein Disulfide Isomerase Family A, Member 4 (PDIA4) (AA 623-638) antibodyPDIA4 适用: 人, 小鼠, 大鼠 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Protein Disulfide Isomerase Family A, Member 4 (PDIA4) antibodyPDIA4 适用: 人 WB, IF, FACS 宿主: 小鼠 Monoclonal 2E2 unconjugated
anti-Protein Disulfide Isomerase Family A, Member 4 (PDIA4) (N-Term) antibodyPDIA4 适用: 人, 小鼠, 大鼠, 犬, Cow, 兔, 斑马鱼, Pig WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Protein Disulfide Isomerase Family A, Member 4 (PDIA4) (AA 355-464) antibodyPDIA4 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2H3 unconjugated
anti-Protein Disulfide Isomerase Family A, Member 4 (PDIA4) (AA 21-645) antibodyPDIA4 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4C6 unconjugated
anti-Protein Disulfide Isomerase Family A, Member 4 (PDIA4) antibodyPDIA4 适用: 人 WB, IF 宿主: 小鼠 Monoclonal 2E11 unconjugated
anti-Protein Disulfide Isomerase Family A, Member 4 (PDIA4) (Internal Region) antibodyPDIA4 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Protein Disulfide Isomerase Family A, Member 4 (PDIA4) (AA 9-37) antibodyPDIA4 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the PDIA4 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store the PDIA4 antibody at -20oC.
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- PDIA4 (Protein Disulfide Isomerase Family A, Member 4 (PDIA4))
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别名
- PDIA4
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背景
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PDIA4 antibody detects Protein disulfide-isomerase A4, also known as ERp72, encoded by the PDIA4 gene. Protein disulfide-isomerase A4 is an endoplasmic reticulum resident enzyme that catalyzes the formation, isomerization, and reduction of disulfide bonds in nascent proteins. PDIA4 antibody provides researchers with a robust reagent to study protein folding, quality control, and endoplasmic reticulum function.
Protein disulfide-isomerase A4 is a member of the protein disulfide-isomerase family, characterized by thioredoxin-like domains that mediate redox reactions. Research using PDIA4 antibody has shown that ERp72 interacts with a wide range of substrates, ensuring correct disulfide bond formation during protein maturation. This activity contributes to protein stability and function, making PDIA4 essential for secretory pathway homeostasis.
PDIA4 also plays a role in the unfolded protein response. Studies with PDIA4 antibody have demonstrated that its expression increases during endoplasmic reticulum stress, reflecting a need for enhanced protein folding capacity. By assisting in protein quality control, PDIA4 protects cells from accumulation of misfolded proteins and prevents activation of apoptosis pathways triggered by unresolved stress.
Beyond folding, Protein disulfide-isomerase A4 has been linked to calcium homeostasis and chaperone activity. Research using PDIA4 antibody has suggested that ERp72 participates in calcium binding and contributes to regulation of calcium dependent processes in the endoplasmic reticulum. These functions underscore the multifunctional nature of PDIA4 in cellular physiology.
Dysregulation of PDIA4 is associated with disease. Elevated expression has been observed in cancers, where increased folding capacity supports tumor cell survival under stress. Conversely, mutations or impaired function may contribute to protein misfolding disorders. Research using PDIA4 antibody has revealed roles in neurodegeneration, diabetes, and cardiovascular disease, reflecting its broad importance across pathologies.
PDIA4 antibody is widely used in western blotting, immunohistochemistry, and immunofluorescence. Western blotting detects ER localized PDIA4, immunohistochemistry highlights expression in secretory tissues, and immunofluorescence reveals endoplasmic reticulum distribution. These applications make PDIA4 antibody a valuable tool in cell biology and disease research.
By supplying validated PDIA4 antibody reagents, NSJ Bioreagents supports research into protein folding, quality control, and disease mechanisms. Detection of Protein disulfide-isomerase A4 provides insight into how protein maturation in the endoplasmic reticulum influences cellular health. -
UniProt
- P13667
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途径
- Thyroid Hormone Synthesis, Cell RedoxHomeostasis
抗原
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