Recombinant PSMC4 抗体
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Quick Overview for Recombinant PSMC4 抗体 (ABIN7882066)
抗原
See all PSMC4 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- PSMC4 Antibody / 26S proteasome regulatory subunit 6B / TBP-7
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纯化方法
- Affinity chromatography
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免疫原
- A synthesized peptide derived from human Tbp7 was used as the immunogen for the PSMC4 antibody.
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亚型
- IgG
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anti-Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 4 (PSMC4) (AA 1-418) antibody
PSMC4 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 4 (PSMC4) (AA 1-418) antibodyPSMC4 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 3G8 unconjugated
anti-Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 4 (PSMC4) (AA 112-181), (Regulatory Subunit) antibodyPSMC4 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 4 (PSMC4) (AA 1-165) antibodyPSMC4 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 4 (PSMC4) antibodyPSMC4 适用: 人 WB, ICC, FACS 宿主: 兔 Monoclonal 24GB1400 unconjugated Recombinant Antibody
anti-Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 4 (PSMC4) (C-Term) antibodyPSMC4 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 4 (PSMC4) (AA 1-50) antibodyPSMC4 适用: 人 WB, IP, IHC (fp) 宿主: 兔 Polyclonal unconjugated
anti-Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 4 (PSMC4) (AA 368-418) antibodyPSMC4 适用: 人 WB, IP, IHC (fp) 宿主: 兔 Polyclonal unconjugated
anti-Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 4 (PSMC4) (N-Term) antibodyPSMC4 适用: 人, 小鼠, 大鼠, 兔, Cow, 犬, 豚鼠, 马, 非洲爪蟾, 猴, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 4 (PSMC4) (N-Term) antibodyPSMC4 适用: 人, 大鼠, 兔, Cow, 犬, 猴 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the PSMC4 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store the PSMC4 antibody at -20oC.
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- PSMC4 (Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 4 (PSMC4))
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别名
- PSMC4
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背景
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PSMC4 antibody recognizes the 26S proteasome regulatory subunit 6B, also known as TBP-7, a protein encoded by the PSMC4 gene. This subunit is a member of the AAA ATPase family and forms part of the 19S regulatory particle of the 26S proteasome. The proteasome is the major protein degradation machinery in eukaryotic cells, responsible for removing damaged, misfolded, or short-lived regulatory proteins through ubiquitin-mediated proteolysis. PSMC4 antibody provides researchers with a key tool to study proteasomal structure and function, particularly in pathways linked to protein turnover, cell cycle regulation, and stress responses.
The 26S proteasome consists of a 20S catalytic core and a 19S regulatory complex. PSMC4 is one of six ATPase subunits within the base of the 19S regulator. These ATPases act as a molecular motor, unfolding ubiquitinated substrates and translocating them into the catalytic chamber for degradation. The role of PSMC4 is critical for energy-dependent substrate processing. Detection with PSMC4 antibody supports studies on proteasome assembly, activity, and substrate specificity.
Dysfunction of proteasome regulation has been linked to neurodegenerative diseases, cancer, and autoimmune disorders. Mutations or altered expression of proteasome subunits, including PSMC4, can disrupt proteostasis and lead to the accumulation of toxic protein aggregates. PSMC4 antibody has therefore been used to examine proteasome activity in conditions such as Parkinson disease, Huntington disease, and multiple myeloma. In cancer biology, changes in proteasome function influence cell proliferation and apoptosis, making it a therapeutic target.
PSMC4 antibody is suitable for use in western blotting, immunohistochemistry, and immunoprecipitation. Western blotting reveals subunit expression within the proteasome complex, while immunohistochemistry highlights localization in tissues with high proteolytic activity, such as liver and brain. Immunoprecipitation using PSMC4 antibody aids in proteasome purification and analysis of protein-protein interactions.
Researchers studying pathways of ubiquitin-mediated degradation, antigen presentation, and stress responses rely on antibodies such as PSMC4 antibody to track proteasome composition and function. NSJ Bioreagents offers validated reagents for investigating this essential protein degradation system across a wide range of experimental applications. -
UniProt
- P43686
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途径
- Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA, Ubiquitin Proteasome Pathway
抗原
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