Recombinant PREPL 抗体
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北京 101111
Quick Overview for Recombinant PREPL 抗体 (ABIN7882049)
抗原
See all PREPL 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- PREPL Antibody / Prolyl endopeptidase-like protein
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纯化方法
- Affinity-chromatography
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免疫原
- A synthesized peptide derived from human PREPL was used as the immunogen for the PREPL antibody.
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亚型
- IgG
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anti-Prolyl Endopeptidase Like Protein (PREPL) antibody
KD Validated PREPL 适用: 人 WB, ICC, FACS, IF (p) 宿主: 兔 Monoclonal 24GB995 unconjugated Recombinant Antibody
anti-Prolyl Endopeptidase Like Protein (PREPL) antibodyKD Validated PREPL 适用: 人 WB, ICC, FACS 宿主: 兔 Monoclonal 24GB990 unconjugated Recombinant Antibody
anti-Prolyl Endopeptidase Like Protein (PREPL) antibodyPREPL 适用: 人, 小鼠, 大鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Prolyl Endopeptidase Like Protein (PREPL) antibodyPREPL 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Prolyl Endopeptidase Like Protein (PREPL) (AA 578-727) antibodyPREPL 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Prolyl Endopeptidase Like Protein (PREPL) (AA 624-652), (C-Term) antibodyPREPL 适用: 人, 小鼠, Hamster WB, IHC (p) 宿主: 兔 Polyclonal RB26878 unconjugated
anti-Prolyl Endopeptidase Like Protein (PREPL) (AA 1-727) antibodyPREPL 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Prolyl Endopeptidase Like Protein (PREPL) (AA 604-699) antibodyPREPL 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the PREPL antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the PREPL antibody at -20oC.
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- PREPL (Prolyl Endopeptidase Like Protein (PREPL))
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别名
- PREPL
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背景
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PREPL antibody detects prolyl endopeptidase-like protein, a cytosolic serine peptidase of the prolyl oligopeptidase family. Unlike other family members, PREPL lacks proteolytic activity due to an inactive catalytic triad, but it retains structural features of peptidases. PREPL is expressed widely, with high levels in brain, kidney, and skeletal muscle, and contributes to intracellular peptide processing, protein-protein interactions, and vesicular trafficking.
Research using PREPL antibody has connected the protein to congenital and neurological disorders. Homozygous deletions affecting PREPL cause hypotonia-cystinuria syndrome, a rare genetic condition characterized by severe neonatal hypotonia, growth retardation, cystinuria, and dysmorphic features. The disorder highlights PREPL's importance in neuromuscular function and metabolic regulation. Additional studies suggest PREPL contributes to vesicle-mediated release of neurotransmitters and hormones, implicating it in neuroendocrine regulation.
Functional studies in animal models have revealed that PREPL knockout mice exhibit growth retardation, motor abnormalities, and altered metabolic phenotypes, consistent with findings in human patients. PREPL has also been implicated in skeletal muscle function, further supporting its role in neuromuscular biology.
PREPL has emerging links to cancer and metabolic disease. Abnormal expression has been detected in certain tumors, although its precise role remains under investigation. Its involvement in vesicular trafficking and peptide regulation suggests PREPL may influence signaling pathways related to growth and proliferation.
Antibodies against PREPL are validated for western blot, immunofluorescence, and immunohistochemistry. These reagents enable reliable detection of PREPL in tissue and cell-based studies, supporting research into peptide regulation, vesicular biology, and neuromuscular disease. Clone-based antibodies provide specificity required for reproducibility in complex biological samples.
NSJ Bioreagents supplies this PREPL antibody for research on congenital disease, metabolism, and neurobiology. -
UniProt
- Q4J6C6
抗原
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