Recombinant PREPL 抗体
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北京 101111
Quick Overview for Recombinant PREPL 抗体 (ABIN7882048)
抗原
See all PREPL 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- PREPL Antibody / Prolyl endopeptidase-like protein
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纯化方法
- Affinity chromatography
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免疫原
- A synthesized peptide derived from human PREPL was used as the immunogen for the PREPL antibody.
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亚型
- IgG
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anti-Prolyl Endopeptidase Like Protein (PREPL) antibody
KD Validated PREPL 适用: 人 WB, ICC, FACS, IF (p) 宿主: 兔 Monoclonal 24GB995 unconjugated Recombinant Antibody
anti-Prolyl Endopeptidase Like Protein (PREPL) antibodyKD Validated PREPL 适用: 人 WB, ICC, FACS 宿主: 兔 Monoclonal 24GB990 unconjugated Recombinant Antibody
anti-Prolyl Endopeptidase Like Protein (PREPL) antibodyPREPL 适用: 人, 小鼠, 大鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Prolyl Endopeptidase Like Protein (PREPL) antibodyPREPL 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Prolyl Endopeptidase Like Protein (PREPL) (AA 578-727) antibodyPREPL 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Prolyl Endopeptidase Like Protein (PREPL) (AA 624-652), (C-Term) antibodyPREPL 适用: 人, 小鼠, Hamster WB, IHC (p) 宿主: 兔 Polyclonal RB26878 unconjugated
anti-Prolyl Endopeptidase Like Protein (PREPL) (AA 1-727) antibodyPREPL 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Prolyl Endopeptidase Like Protein (PREPL) (AA 604-699) antibodyPREPL 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the PREPL antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the PREPL antibody at -20oC.
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- PREPL (Prolyl Endopeptidase Like Protein (PREPL))
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别名
- PREPL
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背景
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PREPL antibody detects Prolyl endopeptidase-like protein, encoded by the PREPL gene. This protein belongs to the prolyl oligopeptidase family of serine peptidases, but unlike many of its relatives, PREPL is thought to have limited or absent catalytic activity. Instead, it is believed to function as a scaffolding or regulatory protein influencing peptide processing, vesicle trafficking, and synaptic transmission. PREPL antibody provides an important reagent for studying rare genetic disease, peptide metabolism, and neurological function.
Mutations in PREPL cause a rare genetic disorder known as hypotonia-cystinuria syndrome, characterized by neonatal hypotonia, muscle weakness, and cystinuria due to loss of function in both PREPL and SLC3A1. Research using PREPL antibody has revealed that absence of Prolyl endopeptidase-like protein disrupts normal vesicle trafficking and neurotransmitter release, contributing to hypotonia and neurological deficits. Although the precise enzymatic role of PREPL remains unclear, its presence in synaptic vesicles suggests it contributes to regulated peptide handling and signaling in the nervous system.
Beyond hypotonia-cystinuria syndrome, alterations in PREPL expression have been studied in broader contexts such as growth, appetite regulation, and endocrine function. Research with PREPL antibody has demonstrated its expression in brain and endocrine tissues, where it may modulate hormone release and metabolic signaling. Some studies suggest that PREPL deficiency influences growth hormone secretion, highlighting its potential role in development. These findings make PREPL an interesting target in both rare disease and general physiology.
PREPL antibody is applied in western blotting, immunohistochemistry, and immunofluorescence. Western blotting demonstrates tissue specific expression, especially in brain and muscle. Immunohistochemistry highlights its distribution in endocrine and neuronal tissues, while immunofluorescence confirms subcellular localization to vesicular structures. Together, these methods provide insights into PREPL's role in vesicle biology and signaling. Functional studies supported by PREPL antibody include knockout models where absence of PREPL reveals physiological consequences at cellular and organismal levels.
By supplying validated PREPL antibody reagents, NSJ Bioreagents supports research into neurobiology, peptide regulation, and rare disease. Detection of Prolyl endopeptidase-like protein provides an essential tool for understanding how peptide handling and vesicle trafficking affect health and disease. -
UniProt
- Q4J6C6
抗原
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